{
  "abstract": "Plant essential oils (EOs) exhibit promising anxiolytic activity, but their application may be constrained by adverse motor effects arising from interactions with neural circuits controlling movement. Here, we investigated the anxiolytic-like effects and motor impairment liability of EOs from Pimenta pseudocaryophyllus, Melissa officinalis, Matricaria chamomilla, Lippia alba, Salvia rosmarinus, Ocimum basilicum, Spiranthera odoratissima, and Cymbopogon citratus, integrating computational target prediction with behavioral pharmacology. Prioritized EO constituents were subjected to target prediction, molecular docking, and 100-ns molecular dynamics simulations to identify molecular mechanisms potentially associated with motor impairment. Male and female Swiss mice received oral vehicle 10 mL/kg, EOs (10, 100, or 500 mg/kg) or diazepam (DZP 1 or 5 mg/kg), followed by the evaluation of anxiolytic-like behavior and motor coordination in the elevated plus maze and rotarod test, respectively. In silico analyses involving docking and molecular dynamics simulations of computationally prioritized EO constituents identified candidate targets within M1 and M2 receptors. All EOs exhibited anxiolytic-like activity at the intermediate dose. Motor impairment varied markedly among EOs. Integrating computational target prediction with behavioral assessment identified distinct motor liability profiles among EOs.",
  "abstract_shown": true,
  "affiliations": [
    "Graduate Program in Pharmaceutical Sciences, Evangelical University of Goiás, Anápolis 75083-515, Brazil",
    "Institute of Biological Sciences, Federal University of Goiás, Goiânia 74690-900, Brazil",
    "Department of Pharmacology and Therapeutics, University of Ilorin, Ilorin 240003, Nigeria",
    "Department of Physiology, Federal University of Uberlândia, Uberlândia 38405-320, Brazil",
    "Escuela de Ingeniería de Construcción y Transporte, Pontifícia Universidad Católica de Valparaíso, Avda Brasil 2147, Valparaíso 2362804, Chile",
    "Laboratory of Pharmaceutical Development (LADEF), Federal University of São João del-Rei, Divinópolis 35501-296, Brazil",
    "School of Medical and Life Sciences, Pontifical Catholic University of Goiás, Goiânia 74605-010, Brazil",
    "Laboratory for Research, Development & Innovation of Biodiversity Products, State University of Goiás, Anápolis 75132-903, Brazil",
    "Institute of Chemistry and Biotechnology, Federal University of Alagoas, AC Simões Campus, Maceió 57072-970, Brazil"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Alberto Souza Sá Filho",
      "orcid": "0000-0001-9434-4231"
    },
    {
      "affs": [
        1
      ],
      "name": "John Ihayi Ogbu",
      "orcid": "0000-0002-3120-9945"
    },
    {
      "affs": [
        1
      ],
      "name": "Ayobami J. Olusola"
    },
    {
      "affs": [
        2
      ],
      "name": "Saheed Olanrewaju Afolabi"
    },
    {
      "affs": [
        1
      ],
      "name": "Gustavo Rodrigues Pedrino",
      "orcid": "0000-0003-0488-5400"
    },
    {
      "affs": [
        3
      ],
      "name": "Marcos Luiz Ferreira-Neto",
      "orcid": "0000-0002-9695-7100"
    },
    {
      "affs": [
        4
      ],
      "name": "Vicente Aprigliano",
      "orcid": "0000-0002-7285-2742"
    },
    {
      "affs": [
        5
      ],
      "name": "Renê Oliveira do Couto",
      "orcid": "0000-0002-3748-3427"
    },
    {
      "affs": [
        6
      ],
      "name": "Lucas Barbosa Ribeiro de Carvalho",
      "orcid": "0000-0002-9365-7196"
    },
    {
      "affs": [
        6,
        7
      ],
      "name": "Leonardo Luiz Borges"
    },
    {
      "affs": [
        8
      ],
      "name": "Mirely Vitória Farias da Silva",
      "orcid": "0000-0002-3405-9794"
    },
    {
      "affs": [
        8
      ],
      "name": "Edeildo Ferreira da Silva-Júnior",
      "orcid": "0000-0002-1527-4501"
    },
    {
      "affs": [
        0
      ],
      "name": "Antônio Sérgio Nakao de Aguiar",
      "orcid": "0000-0001-9410-9194"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "James Oluwagbamigbe Fajemiroye",
      "orcid": "0000-0001-7440-7581"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3gr3j2ngk8r2h.bib",
  "cited_by": 0,
  "doi": "10.3390/ijms27198786",
  "fulltext_url": "https://europepmc.org/articles/PMC13664909",
  "id": "3gr3j2ngk8r2h",
  "issns": [
    "1422-0067"
  ],
  "landing_url": "https://www.mdpi.com/1422-0067/27/19/8786",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2707|Medicinal Plant Extracts Effects"
    ]
  ],
  "openalex": "W7214893261",
  "pdf_url": "https://europepmc.org/articles/PMC13664909?pdf=render",
  "pmcid": "PMC13664909",
  "pmid": "42884030",
  "published": "2026-09-30",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/3gr3j2ngk8r2h.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:55Z",
      "native_id": "10.3390/ijms27198786",
      "source": "crossref",
      "url": "https://www.mdpi.com/1422-0067/27/19/8786"
    },
    {
      "first_seen": "2026-10-30T12:19:16Z",
      "native_id": "MED:42884030",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42884030"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2707|Medicinal Plant Extracts Effects",
      "subfield": "general"
    }
  ],
  "title": "Anxiolytic Potential of Selected Essential Oils and Their Impact on Motor Function",
  "title_text": "Anxiolytic Potential of Selected Essential Oils and Their Impact on Motor Function",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:16Z",
  "url": "https://research.draconitic.com/paper/3gr3j2ngk8r2h",
  "venue": "International Journal of Molecular Sciences",
  "versions": []
}