{
  "abstract": "Background/Objectives: The hemoglobin–albumin–lymphocyte–platelet (HALP) score is an immune–nutritional biomarker associated with oncological outcomes. We evaluated perioperative HALP trajectories and their association with early postoperative complications after curative esophagectomy. Methods: In this retrospective single-center cohort study, 129 patients undergoing esophagectomy between June 2020 and March 2025 were included. HALP was calculated preoperatively and on postoperative days 1 and 7. Trajectories were analyzed using generalized estimating equations. Discriminative performance was assessed using receiver operating characteristic (ROC) analysis, and independent associations were evaluated using multivariable logistic regression. Results: HALP declined markedly after surgery (median, 28.93 preoperatively, 10.11 on postoperative day 1, and 10.53 on postoperative day 7; p < 0.001). Patients with major complications, anastomotic leakage, or intensive care unit readmission had lower postoperative day 7 HALP values. Postoperative day 7 HALP discriminated intensive care unit readmission (area under the curve [AUC] = 0.769), anastomotic leakage (AUC = 0.734), major complications (AUC = 0.733), and overall complications (AUC = 0.697). Each doubling of postoperative day 7 HALP was independently associated with lower odds of overall complications (odds ratio [OR] = 0.473), major complications (OR = 0.351), anastomotic leakage (OR = 0.383), and intensive care unit readmission (OR = 0.374; all p ≤ 0.002). Preoperative HALP showed limited discriminative performance. Bootstrap-corrected AUCs for the models including age, ASA, and POD7 HALP ranged from 0.696 to 0.737. Conclusions: HALP demonstrates a distinct perioperative trajectory after esophagectomy, with persistent impairment on postoperative day 7 associated with early postoperative morbidity. The potential clinical role of serial HALP assessment requires prospective evaluation.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Anesthesiology, Basaksehir Cam and Sakura City Hospital, Istanbul 34480, Türkiye",
    "Department of General Surgery, Basaksehir Cam and Sakura City Hospital, Istanbul 34480, Türkiye",
    "Department of Gastroenterological Surgery, Basaksehir Cam and Sakura City Hospital, Istanbul 34480, Türkiye",
    "Department of Anesthesiology, Acibadem Mehmet Ali Aydinlar University, Istanbul 34638, Türkiye"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Hürü Ceren Gökduman",
      "orcid": "0000-0003-1904-4954"
    },
    {
      "affs": [
        1
      ],
      "name": "Oğuzhan Aytepe",
      "orcid": "0009-0000-0624-8814"
    },
    {
      "affs": [
        2
      ],
      "name": "Yiğit Düzköylü",
      "orcid": "0000-0001-6894-6896"
    },
    {
      "affs": [
        1
      ],
      "name": "Sercan Yüksel",
      "orcid": "0000-0002-9069-7774"
    },
    {
      "affs": [
        1
      ],
      "name": "Hüsnü Ozan Şevik",
      "orcid": "0000-0001-6381-6726"
    },
    {
      "affs": [
        0
      ],
      "name": "Taner Abdullah",
      "orcid": "0000-0002-2096-4646"
    },
    {
      "affs": [
        3
      ],
      "name": "Mert Şentürk",
      "orcid": "0000-0003-2373-6451"
    },
    {
      "affs": [
        0
      ],
      "name": "Funda Gümüş Özcan",
      "orcid": "0000-0003-0641-7977"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3gvj0c60jgyvr.bib",
  "cited_by": 0,
  "doi": "10.3390/jcm15218716",
  "fulltext_url": null,
  "id": "3gvj0c60jgyvr",
  "issns": [
    "2077-0383"
  ],
  "landing_url": "https://www.mdpi.com/2077-0383/15/21/8716",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-08",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/3gvj0c60jgyvr.ris",
  "sources": [
    {
      "first_seen": "2026-11-10T00:21:41Z",
      "native_id": "10.3390/jcm15218716",
      "source": "crossref",
      "url": "https://www.mdpi.com/2077-0383/15/21/8716"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "journal-openalex:F27",
      "subfield": "general"
    }
  ],
  "title": "Perioperative Dynamics of the Hemoglobin–Albumin–Lymphocyte–Platelet (HALP) Score and Early Morbidity After Curative Esophagectomy",
  "title_text": "Perioperative Dynamics of the Hemoglobin–Albumin–Lymphocyte–Platelet (HALP) Score and Early Morbidity After Curative Esophagectomy",
  "type": "peer-reviewed",
  "updated_at": "2026-11-10T00:21:41Z",
  "url": "https://research.draconitic.com/paper/3gvj0c60jgyvr",
  "venue": "Journal of Clinical Medicine",
  "versions": []
}