{
  "abstract": "Background: Identifying robust neural signatures of posttraumatic stress disorder (PTSD) symptoms is important to facilitate precision psychiatry and help in understanding and treatment of the disorder. Emergent research suggests structural covariance of early visual regions is associated with later PTSD development. However, large-scale analyses are needed - in heterogeneous samples of trauma-exposed and trauma naive individuals - to determine if such a neural signature is a robust - and potentially a pretrauma - marker of vulnerability. Methods: We analyzed data from the ENIGMA-PTSD dataset (n = 2,814) and the Human Connectome Project - Young Adult (HCP-YA) dataset (n = 890) to investigate whether structural covariance of early visual cortex is associated with either PTSD symptoms or perceived stress. Structural covariance was derived from a multimodal pattern previously identified in recent trauma survivors, and participant loadings on the profile were included in linear mixed effects models to evaluate associations with stress. Results: Early visual cortex covariance loadings were negatively associated with PTSD symptoms in the ENIGMA-PTSD dataset. The relationship persisted when accounting for prior childhood maltreatment; supporting PTSD symptom specificity, no relationship was observed with depressive symptoms and no association was observed between loadings and perceived stress measures in the HCP-YA dataset. Conclusion: Structural covariance of early visual cortex was robustly associated with PTSD symptoms across an international, heterogeneous sample of trauma survivors. Future studies should aim to identify specific mechanisms that underlie structural alterations in the visual cortex to better understand posttrauma psychopathology.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 98,
  "authors": [
    {
      "name": "Nathaniel Harnett"
    },
    {
      "name": "Soumyaa Joshi"
    },
    {
      "name": "Poornima Kumar"
    },
    {
      "name": "Courtney Russell"
    },
    {
      "name": "Daniel Dillon"
    },
    {
      "name": "Justin Baker"
    },
    {
      "name": "Diego Pizzagalli"
    },
    {
      "name": "Milissa Kaufman"
    },
    {
      "name": "Lisa Nickerson"
    },
    {
      "name": "Neda Jahanshad"
    },
    {
      "name": "Lauren Salminen"
    },
    {
      "name": "Sophia Thomopoulos"
    },
    {
      "name": "Jessie Frijling"
    },
    {
      "name": "Dick Veltman"
    },
    {
      "name": "Saskia B.J. Koch"
    },
    {
      "name": "Laura Nawijn"
    },
    {
      "name": "Mirjam van Zuiden"
    },
    {
      "name": "Ye Zhu"
    },
    {
      "name": "Gen Li"
    },
    {
      "name": "Jonathan Ipser"
    },
    {
      "name": "Xi Zhu"
    },
    {
      "name": "Orren Ravid"
    },
    {
      "name": "Sigal Zilcha-Mano"
    },
    {
      "name": "Amit Lazarov"
    },
    {
      "name": "Benjamin Suarez-Jimenez"
    },
    {
      "name": "Delin Sun"
    },
    {
      "name": "Ahmed Hussain"
    },
    {
      "name": "Ashley Huggins"
    },
    {
      "name": "Tanja Jovanovic"
    },
    {
      "name": "Sanne J.H. van Rooij"
    },
    {
      "name": "Negar Fani"
    },
    {
      "name": "Anna Hudson"
    },
    {
      "name": "Anika Sierk"
    },
    {
      "name": "Antje Manthey"
    },
    {
      "name": "Henrik Walter"
    },
    {
      "name": "Nic J.A. van der Wee"
    },
    {
      "name": "Steven J.A. van der Werff"
    },
    {
      "name": "Robert R.J.M. Vermeiren"
    },
    {
      "name": "Pavel Říha"
    },
    {
      "name": "Lauren A.M. Lebois"
    },
    {
      "name": "Isabelle Rosso"
    },
    {
      "name": "Elizabeth Olson"
    },
    {
      "name": "Israel Liberzon"
    },
    {
      "name": "Mike Angstadt"
    },
    {
      "name": "Seth Disner"
    },
    {
      "name": "Scott Sponheim"
    },
    {
      "name": "Sheri-Michelle Koopowitz"
    },
    {
      "name": "David Hofmann"
    },
    {
      "name": "Rongfeng Qi"
    },
    {
      "name": "Adi Maron-Katz"
    },
    {
      "name": "Austin Kunch"
    },
    {
      "name": "Hong Xie"
    },
    {
      "name": "Wissam El-Hage"
    },
    {
      "name": "Hannah Berg"
    },
    {
      "name": "Steven Bruce"
    },
    {
      "name": "Katie Mclaughlin"
    },
    {
      "name": "Matthew Peverill"
    },
    {
      "name": "Kelly Sambrook"
    },
    {
      "name": "Marisa Ross"
    },
    {
      "name": "Ryan Herringa"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3gy62m2yhs50a.bib",
  "cited_by": 3,
  "doi": "10.1016/j.bpsc.2025.07.005",
  "fulltext_url": null,
  "id": "3gy62m2yhs50a",
  "issns": [
    "2451-9022"
  ],
  "landing_url": "https://inserm.hal.science/inserm-05860924v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.mhep"
    ],
    [
      "hal",
      "2.sdv.mhep.psm"
    ],
    [
      "openalex",
      "3203|Posttraumatic Stress Disorder Research"
    ]
  ],
  "openalex": "W4412599437",
  "pdf_url": "https://inserm.hal.science/inserm-05860924/document",
  "pmcid": null,
  "pmid": "40166540",
  "published": "2026-11-12",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/3gy62m2yhs50a.ris",
  "sources": [
    {
      "first_seen": "2026-11-12T12:20:56Z",
      "native_id": "inserm-05860924",
      "source": "hal",
      "url": "https://inserm.hal.science/inserm-05860924v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:0.sdv",
      "subfield": "general"
    },
    {
      "field": "medicine",
      "origin": "hal:2.sdv.mhep.psm",
      "subfield": "psychiatry"
    }
  ],
  "title": "Structural Covariance of Early Visual Cortex Is Negatively Associated With Posttraumatic Stress Disorder Symptoms: A Mega-Analysis From the ENIGMA PTSD Working Group",
  "title_text": "Structural Covariance of Early Visual Cortex Is Negatively Associated With Posttraumatic Stress Disorder Symptoms: A Mega-Analysis From the ENIGMA PTSD Working Group",
  "type": "peer-reviewed",
  "updated_at": "2026-11-13T12:20:03Z",
  "url": "https://research.draconitic.com/paper/3gy62m2yhs50a",
  "venue": "Biological Psychiatry: Cognitive Neuroscience and Neuroimaging",
  "versions": []
}