{
  "abstract": "Background/Objectives: Early recurrence (ER) after curative-intent resection of perihilar cholangiocarcinoma (PHC) is associated with poor prognosis. However, simple preoperative predictors remain insufficiently defined. This study aimed to identify preoperative factors associated with ER and explore a risk classification. Methods: We retrospectively analyzed 108 patients who underwent curative-intent resection for PHC at a single institution between 2007 and 2023. ER was defined as recurrence within 1 year after surgery. Cox proportional hazards regression was used to identify associated factors. Results: ER occurred in 24 patients (22.2%). Multivariable analysis identified younger age (hazard ratio [HR] = 0.942), higher carcinoembryonic antigen (CEA; HR = 1.115), higher carbohydrate antigen 19-9 (CA19-9; HR = 1.001), and higher neutrophil-to-lymphocyte ratio (NLR; HR = 1.404) as factors associated with ER. In an exploratory classification, one point was assigned for age < 61 years, CEA ≥ 5.4 ng/mL, CA19-9 ≥ 89.4 U/mL, and NLR ≥ 2.037. Among 105 patients with complete data, the estimated 1-year recurrence rate was 70.0% in patients with 3–4 points (n = 10), versus 17.4% in those with 0–2 points (n = 95; p < 0.001). Bootstrap analysis suggested optimism in the score’s apparent discrimination when cutoff optimization was considered (optimism-corrected C-index, 0.668). Conclusions: Age, CEA, CA19-9, and NLR were associated with ER after PHC resection. The exploratory classification requires external validation before clinical use.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Hepatobiliary Pancreatic and Transplant Surgery, Mie University Graduate School of Medicine, Tsu 514-8507, Japan"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yu Fujimura"
    },
    {
      "affs": [
        0
      ],
      "name": "Naohisa Kuriyama",
      "orcid": "0000-0002-9668-0500"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuki Segi"
    },
    {
      "affs": [
        0
      ],
      "name": "Haruna Komatsubara",
      "orcid": "0009-0008-6856-4992"
    },
    {
      "affs": [
        0
      ],
      "name": "Kazuyuki Gyoten"
    },
    {
      "affs": [
        0
      ],
      "name": "Takahiro Ito",
      "orcid": "0000-0002-1876-3052"
    },
    {
      "affs": [
        0
      ],
      "name": "Aoi Hayasaki"
    },
    {
      "affs": [
        0
      ],
      "name": "Takehiro Fujii",
      "orcid": "0000-0002-4454-4283"
    },
    {
      "affs": [
        0
      ],
      "name": "Yusuke Iizawa"
    },
    {
      "affs": [
        0
      ],
      "name": "Yasuhiro Murata"
    },
    {
      "affs": [
        0
      ],
      "name": "Akihiro Tanemura"
    },
    {
      "affs": [
        0
      ],
      "name": "Masashi Kishiwada",
      "orcid": "0000-0003-4408-2960"
    },
    {
      "affs": [
        0
      ],
      "name": "Shugo Mizuno",
      "orcid": "0000-0002-2253-544X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3h52zm2henphz.bib",
  "cited_by": 0,
  "doi": "10.3390/cancers18213568",
  "fulltext_url": null,
  "id": "3h52zm2henphz",
  "issns": [
    "2072-6694"
  ],
  "landing_url": "https://www.mdpi.com/2072-6694/18/21/3568",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-06",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/3h52zm2henphz.ris",
  "sources": [
    {
      "first_seen": "2026-11-06T12:21:21Z",
      "native_id": "10.3390/cancers18213568",
      "source": "crossref",
      "url": "https://www.mdpi.com/2072-6694/18/21/3568"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "issn:2072-6694",
      "subfield": "oncology"
    }
  ],
  "title": "Preoperative Risk Classification for Early Recurrence After Curative-Intent Resection of Perihilar Cholangiocarcinoma: A Single-Center Retrospective Study",
  "title_text": "Preoperative Risk Classification for Early Recurrence After Curative-Intent Resection of Perihilar Cholangiocarcinoma: A Single-Center Retrospective Study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T00:23:01Z",
  "url": "https://research.draconitic.com/paper/3h52zm2henphz",
  "venue": "Cancers",
  "versions": []
}