{
  "abstract": "Background/objectives\n\nDecision-making in advanced cancer care is intertwined with diagnostic profiling, prognostic communication, supportive care, and anticancer treatment selection. An author-developed D-S-T × B/C/E conceptual mapping scaffold-three decision/action domains (Diagnosis, Supportive care, Therapy) and three evaluative dimensions (Biological, Clinical, Existential)-was used to organise the literature, to identify coverage gaps and recurring framework categories, and, as a secondary conceptual synthesis objective, to derive a candidate integrative framework.Methods\n\nThe review was conducted according to the Joanna Briggs Institute (JBI) methodology for scoping reviews, pre-registered on OSF, and reported per PRISMA-ScR. PubMed was searched on 21 June 2026, and the final evidence set was derived solely from this search. Eligible records concerning adults with advanced cancer were dual-screened and charted using a structured form.Results\n\nEighty-two records (2010-2026) were included. Under the strict D-S-T × B/C/E matrix, Supportive care showed the highest joint coverage, particularly S × C (59/82, 72.0%), whereas D × B and D × E were the least represented cells (13/82 each, 15.9%). Eight recurring framework categories were inductively derived from the charted framework descriptors, led by early integrated palliative care (30/82) and prognosis-informed shared decision-making (27/82). Twenty-two records met an emergence-candidate screen defined at the synthesis stage, of which three received the maximum cross-axis coupling score of 6/6 from both reviewers.Conclusions\n\nThe advanced-cancer decision-framework literature clusters around a small number of architectures with uneven D-S-T × B/C/E coverage. Diagnosis-centred frameworks coupled with biological or existential dimensions were relatively under-represented within our mapping and represent priority targets for future primary research; the proposed Adaptive framework provides one structure in which this research could be conducted.",
  "abstract_shown": true,
  "affiliations": [
    "Division of Medical Oncology, Department of Internal Medicine, Sapporo Medical University School of Medicine, S-1 W-16, Chuo-ku, Sapporo 060-8543, Hokkaido, Japan.",
    "Higashi Sapporo Hospital, 3-3-7-35 Higashi Sapporo, Shiroishi-ku, Sapporo 003-8585, Hokkaido, Japan."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Kazuyuki Murase",
      "orcid": "0000-0003-2642-8665"
    },
    {
      "affs": [
        1
      ],
      "name": "Yusuke Sugama",
      "orcid": "0000-0003-2899-0512"
    },
    {
      "affs": [
        0
      ],
      "name": "Yohei Arihara"
    },
    {
      "affs": [
        0
      ],
      "name": "Kohichi Takada",
      "orcid": "0000-0002-1393-9442"
    },
    {
      "affs": [
        1
      ],
      "name": "Kunihiko Ishitani",
      "orcid": "0000-0001-8420-1608"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3hagqm1k0c8p2.bib",
  "cited_by": 0,
  "doi": "10.3390/cancers18193245",
  "fulltext_url": "https://europepmc.org/articles/PMC13664350",
  "id": "3hagqm1k0c8p2",
  "issns": [
    "2072-6694"
  ],
  "landing_url": "https://europepmc.org/article/MED/42882939",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2739|Palliative Care and End-of-Life Issues"
    ]
  ],
  "openalex": "W7221167623",
  "pdf_url": "https://europepmc.org/articles/PMC13664350?pdf=render",
  "pmcid": "PMC13664350",
  "pmid": "42882939",
  "published": "2026-10-08",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/3hagqm1k0c8p2.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:00Z",
      "native_id": "MED:42882939",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42882939"
    },
    {
      "first_seen": "2026-10-30T12:19:58Z",
      "native_id": "10.3390/cancers18193245",
      "source": "crossref",
      "url": "https://www.mdpi.com/2072-6694/18/19/3245"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2739|Palliative Care and End-of-Life Issues",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Mapping Integrative Decision-Making Frameworks in Advanced Cancer Care: A Scoping Review of Diagnostic, Supportive-Care, and Therapeutic Integration.",
  "title_text": "Mapping Integrative Decision-Making Frameworks in Advanced Cancer Care: A Scoping Review of Diagnostic, Supportive-Care, and Therapeutic Integration.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:58Z",
  "url": "https://research.draconitic.com/paper/3hagqm1k0c8p2",
  "venue": "Cancers",
  "versions": []
}