{
  "abstract": "Background: The role of human papillomavirus (HPV) in cardiovascular disease (CVD) remains unclear. We aimed to investigate the associations of HPV infection with incident CVD and CVD-related mortality. Methods and findings: In this population-based matched cohort study based on Swedish national registers, we identified women with an incident HPV infection during 2006 and 2024 (N = 497,445), and age-matched each woman with five women without infection. The time-varying associations between HPV infection and CVD were assessed using flexible parametric models, which also provided hazard ratios (HRs) and 95% confidence intervals (CIs) after adjusting for sociodemographic factors, HPV vaccination, chronic diseases, and parental history of related diseases. To control for familial factors, we also compared 143,787 women with HPV infection to their 174,637 unaffected full siblings. Conclusions: HPV infection was associated with increased risk of incident CVD and CVD-related mortality. The findings suggested that clinicians should be aware of a slightly elevated CVD risk in women with HPV, especially during the first year following an infection. However, given the small absolute difference, women should not be unduly concerned. Why was this study done?: What did the researchers do and find?: What do these findings mean?: In a large Swedish population study, Yunyang Deng and colleagues found that women with human papillomavirus (HPV) infection had slightly higher rates of cardiovascular disease and cardiovascular-related mortality than those without HPV, with the strongest associations observed during the first year after infection.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden",
    "Clinical Research Unit, Shanghai Disabled Persons’ Federation Key Laboratory of Intelligent Rehabilitation Assistive Devices and Technologies, Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), Tongji University School of Medicine, Shanghai, China",
    "Laboratory of Mental Health Research, Tongji University School of Medicine, Shanghai, China",
    "Department of Paediatrics, Örebro University Hospital, Örebro, Sweden",
    "Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, United States of America",
    "Institute for Advanced Study, Tongji University, Shanghai, China"
  ],
  "article_type": "Research Article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yunyang Deng"
    },
    {
      "affs": [
        1
      ],
      "name": "Mark Clements"
    },
    {
      "affs": [
        2
      ],
      "name": "Chaonan Shen"
    },
    {
      "affs": [
        3
      ],
      "name": "Jonas F. Ludvigsson"
    },
    {
      "affs": [
        4
      ],
      "name": "Qing Shen"
    },
    {
      "affs": [
        5
      ],
      "name": "Jiayao Lei"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3harr5w0p4p3h.bib",
  "cited_by": 0,
  "doi": "10.1371/journal.pmed.1005222",
  "fulltext_url": "https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1005222",
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  "issns": [
    "1549-1676"
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  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
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      "openalex",
      "2713|Cervical Cancer and HPV Research"
    ],
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      "plos",
      "/Biology and life sciences/Cell biology/Cytology"
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    ],
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      "/Medicine and health sciences/Medical conditions/Cardiovascular diseases"
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      "plos",
      "/Medicine and health sciences/Medical conditions/Cardiovascular diseases/Cardiovascular diseases in women"
    ],
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      "plos",
      "/Medicine and health sciences/Medical conditions/Infectious diseases/Sexually transmitted diseases/Human papillomavirus infection"
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      "/Medicine and health sciences/Medical conditions/Infectious diseases/Viral diseases/Human papillomavirus infection"
    ],
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      "/Medicine and health sciences/Oncology/Cancer risk factors"
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      "/Medicine and health sciences/Oncology/Cancers and neoplasms/Gynecological tumors/Cervical cancer"
    ],
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      "/Medicine and health sciences/Urology/Genitourinary infections/Human papillomavirus infection"
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  "pmcid": null,
  "pmid": null,
  "published": "2026-09-01",
  "publisher": "Public Library of Science",
  "ris": "https://research.draconitic.com/paper/3harr5w0p4p3h.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:02Z",
      "native_id": "10.1371/journal.pmed.1005222",
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  "subjects": [
    {
      "field": "medicine",
      "origin": "plos:cardiovascular diseases",
      "subfield": "cardiovascular"
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    {
      "field": "medicine",
      "origin": "plos:infectious diseases",
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      "field": "medicine",
      "origin": "plos:oncology",
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  "title": "Human papillomavirus infection and risk of cardiovascular disease: A population-based matched cohort study with sibling analysis",
  "title_text": "Human papillomavirus infection and risk of cardiovascular disease: A population-based matched cohort study with sibling analysis",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:02Z",
  "url": "https://research.draconitic.com/paper/3harr5w0p4p3h",
  "venue": "PLOS Medicine",
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}