{
  "abstract": "Objectives\n\nCollapsin response-mediator protein 5 (CRMP5)-IgG is an acknowledged biomarker in the International Consortium on Optic Neuritis (ICON) diagnostic criteria for optic neuritis (ON), but these criteria have not been validated in CRMP5-IgG+ON.Methods\n\nWe evaluated the ICON and Acute Optic Neuritis Network (ACON) criteria for CRMP5-IgG+ON, using patients with late-onset (age ≥50 years) aquaporin-4-IgG-positive (AQP4-IgG+)-ON or myelin-oligodendrocyte glycoprotein antibody (MOG-IgG+)-ON for comparison. We developed the \"CRMP score,\" based on typical CRMP5-IgG+ON clinical features, to guide CRMP5 antibody testing in ON.Results\n\nThe study included 17 patients with CRMP5-IgG+, 11 with AQP4-IgG+ON, and 13 with MOG-IgG+ON. Application of ICON criteria yielded no \"definite ON\" and 1 \"probable ON\" diagnosis among the 17 CRMP5-IgG+ cases, but definite ON diagnoses for 6 of 11 AQP4-IgG+ (55%, p = 0.003) and 7 of 13 MOG-IgG+ cases (54%, p = 0.001). ACON criteria yielded definite ON diagnoses for 2 (12%) CRMP5-IgG+ON, 10 (91%) of the AQP4-IgG+ON, and 13 (100%) of the MOG-IgG+ON (p < 0.001). A CRMP score ≥1 identified CRMP5-IgG+ON with a sensitivity of 88.2% and a specificity of 87.5%.Discussion\n\nICON and ACON criteria for ON diagnosis identified only a minority of CRMP5-IgG+ON cases; thus, we developed the \"CRMP\" score to aid their identification in clinical practice.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Neurology and Center for Multiple Sclerosis and Autoimmune Neurology, Mayo Clinic, Rochester, MN.",
    "Neurology IV - Neuroimmunology and Neuromuscular Diseases Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.",
    "Department of Ophthalmology, Cleveland Clinic Foundation, OH.",
    "Department of Ophthalmology, Mayo Clinic, Rochester, MN.",
    "Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN; and.",
    "Department of Ophthalmology, The Permanente Medical Group, Kaiser Permanente-Northern California, Roseville, CA."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Alessandro Dinoto",
      "orcid": "0000-0002-3249-4792"
    },
    {
      "affs": [
        2
      ],
      "name": "Devon A Cohen",
      "orcid": "0000-0002-0160-8435"
    },
    {
      "affs": [
        0
      ],
      "name": "Laura Cacciaguerra",
      "orcid": "0000-0001-9342-2410"
    },
    {
      "affs": [
        0
      ],
      "name": "Nanthaya Tisavipat",
      "orcid": "0000-0002-4021-6450"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Stephanie B Syc-Mazurek",
      "orcid": "0000-0002-9549-6648"
    },
    {
      "affs": [
        0,
        4
      ],
      "name": "Vanda A Lennon",
      "orcid": "0000-0003-1910-1576"
    },
    {
      "affs": [
        5
      ],
      "name": "M Tariq Bhatti",
      "orcid": "0000-0001-7190-5630"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Deena A Tajfirouz",
      "orcid": "0000-0001-8419-8728"
    },
    {
      "affs": [
        3
      ],
      "name": "Kevin D Chodnicki",
      "orcid": "0000-0002-6815-8272"
    },
    {
      "affs": [
        0,
        4
      ],
      "name": "Sean J Pittock",
      "orcid": "0000-0002-6140-5584"
    },
    {
      "affs": [
        0,
        4
      ],
      "name": "Eoin P Flanagan",
      "orcid": "0000-0002-6661-2910"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "John J Chen",
      "orcid": "0000-0003-3644-7528"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3hbbwhdctybtw.bib",
  "cited_by": 0,
  "doi": "10.1212/nxi.0000000000200666",
  "fulltext_url": "https://europepmc.org/articles/PMC13690358",
  "id": "3hbbwhdctybtw",
  "issns": [
    "2332-7812"
  ],
  "landing_url": "https://europepmc.org/article/MED/42905998",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2728|Autoimmune Neurological Disorders and Treatments"
    ]
  ],
  "openalex": "W7223105005",
  "pdf_url": "https://europepmc.org/articles/PMC13690358?pdf=render",
  "pmcid": "PMC13690358",
  "pmid": "42905998",
  "published": "2026-10-21",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/3hbbwhdctybtw.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:53Z",
      "native_id": "MED:42905998",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42905998"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2728|Autoimmune Neurological Disorders and Treatments",
      "subfield": "neurology"
    }
  ],
  "title": "Application of Optic Neuritis Diagnostic Criteria in Autoimmune Paraneoplastic CRMP5 Optic Neuropathy and Development of the \"CRMP\" Score.",
  "title_text": "Application of Optic Neuritis Diagnostic Criteria in Autoimmune Paraneoplastic CRMP5 Optic Neuropathy and Development of the \"CRMP\" Score.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:53Z",
  "url": "https://research.draconitic.com/paper/3hbbwhdctybtw",
  "venue": "Neurology(R) neuroimmunology & neuroinflammation",
  "versions": []
}