{
  "abstract": "Background: This study aimed to investigate the clinical features, treatment responses, and outcomes of pediatric patients with Crohn’s disease (CD) and perianal disease (PD) in China, with a particular focus on age at diagnosis.\n\nMethods: We retrospectively analyzed 144 children diagnosed with CD between 2015 and 2024. Patients were divided into PD and non-PD groups and further stratified by age at diagnosis into very-early onset (VEO-IBD, < 6 years) and late-onset disease (LO; 6–18 years). The clinical, endoscopic, and genetic data were compared between the groups.\n\nResults: The overall prevalence of PD was 57/144 (39.58%). VEO-IBD cases accounted for 44/144 (30.56%) of cases, of whom 22/44 (50.00%) had concurrent PD; among these VEO-PD patients, the monogenic mutation rate was 17/22 (77.27%), predominantly involving IL-10RA. In the full cohort, PD was associated with increased colonic involvement (25/57 [43.86%] vs. 17/87 [19.54%], P < 0.05), greater disease severity (severe PCDAI: 25/57 [43.86%] vs. 20/87 [22.99%], P < 0.05), and lower clinical remission rates (41/57 [71.93%] vs. 83/87 [95.40%], P < 0.05). In the LO subgroup, patients with PD were treated with biologic agents significantly earlier, with clinical remission of perianal lesions reaching 30/35 (85.71%).\n\nConclusions: VEO-IBD with PD was associated with monogenic mutations, greater disease activity, and lower clinical remission. VEO-PD had poorer outcomes than VEO-IBD without PD, although mortality was similar. In selected monogenic VEO-IBD patients, thalidomide and/or HSCT may be individualized options, but thalidomide should not be generalized to all VEO-IBD.\n\nSupplementary Information: The online version contains supplementary material available at https://doi.org/10.1186/s12876-026-05485-y.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Gastroenterology, Capital Center for Children’s Health, Capital Medical University, Beijing, 100020 China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Mingran Mi"
    },
    {
      "affs": [
        0
      ],
      "name": "Meng Jin"
    },
    {
      "affs": [
        0
      ],
      "name": "Li Meng"
    },
    {
      "affs": [
        0
      ],
      "name": "Youzhe Gong"
    },
    {
      "affs": [
        0
      ],
      "name": "Xuemei Zhong"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3hf573ty78zxn.bib",
  "cited_by": 0,
  "doi": "10.1186/s12876-026-05485-y",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13733119/",
  "id": "3hf573ty78zxn",
  "issns": [
    "1471-230X"
  ],
  "landing_url": "https://doi.org/10.1186/s12876-026-05485-y",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research"
    ],
    [
      "openalex",
      "2715|Inflammatory Bowel Disease"
    ]
  ],
  "openalex": "W7225151778",
  "pdf_url": "https://link.springer.com/content/pdf/10.1186/s12876-026-05485-y.pdf",
  "pmcid": "PMC13733119",
  "pmid": "42977903",
  "published": "2026-11-03",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/3hf573ty78zxn.ris",
  "sources": [
    {
      "first_seen": "2026-11-08T12:22:58Z",
      "native_id": "PMC13733119",
      "source": "pmc",
      "url": "https://doi.org/10.1186/s12876-026-05485-y"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2715|Inflammatory Bowel Disease",
      "subfield": "general"
    }
  ],
  "title": "Clinical features and outcomes of perianal disease in pediatric-onset Crohn’s disease: A comparative analysis according to age at diagnosis",
  "title_text": "Clinical features and outcomes of perianal disease in pediatric-onset Crohn’s disease: A comparative analysis according to age at diagnosis",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:22:58Z",
  "url": "https://research.draconitic.com/paper/3hf573ty78zxn",
  "venue": "BMC Gastroenterology",
  "versions": []
}