{
  "abstract": "The prognostic relevance of the relative change in right ventricular stroke work index (RVSWI) after balloon pulmonary angioplasty (BPA) in chronic thromboembolic pulmonary hypertension (CTEPH) remains uncertain. This retrospective single-center study included 38 patients with CTEPH. Follow-up began at post-BPA catheterization. Relative change in RVSWI (%RVSWI; negative values indicate reduction) and conventional measures were compared using Cox models and direction-fixed C-indices. Bootstrap resampling assessed selection optimism across 14 candidates. RVSWI decreased from 16.96 to 9.83 g·m/m²/beat. During a median 4.1 years, 7 patients reached the composite endpoint of all-cause death or heart failure hospitalization. A smaller reduction was associated with higher risk (hazard ratio 1.24 per 1 percentage-point increase in %RVSWI, 95% confidence interval 1.06-1.44; p = 0.007). %RVSWI had the highest apparent C-index (0.942, 95% confidence interval 0.86-0.99), but its difference from achieved mean pulmonary artery pressure (C-index 0.855) was not statistically distinguishable. %RVSWI ranked first in 62% of bootstrap resamples; the optimism-corrected C-index was 0.922. Component log-ratios were essentially uncorrelated (r = 0.01, 95% confidence interval -0.31 to 0.33). Greater RVSWI reduction after BPA was associated with better prognosis. With seven events, these findings are hypothesis-generating; superiority over conventional measures and the physiological interpretation of the SVI component remain unestablished.",
  "abstract_shown": true,
  "affiliations": [
    "The Second Department of Internal Medicine University of Toyama Toyama Japan."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ryuichi Ushijima",
      "orcid": "0000-0002-4543-596X"
    },
    {
      "affs": [
        0
      ],
      "name": "Teruhiko Imamura"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuki Hida"
    },
    {
      "affs": [
        0
      ],
      "name": "Hiroshi Ueno",
      "orcid": "0000-0001-9747-2511"
    },
    {
      "affs": [
        0
      ],
      "name": "Koichiro Kinugawa"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3hp9vqw9fgyq7.bib",
  "cited_by": 0,
  "doi": "10.1002/pul2.70430",
  "fulltext_url": "https://europepmc.org/articles/PMC13686345",
  "id": "3hp9vqw9fgyq7",
  "issns": [
    "2045-8932",
    "2045-8940"
  ],
  "landing_url": "https://europepmc.org/article/MED/42910036",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2740|Pulmonary Hypertension Research and Treatments"
    ]
  ],
  "openalex": "W7223088744",
  "pdf_url": "https://europepmc.org/articles/PMC13686345?pdf=render",
  "pmcid": "PMC13686345",
  "pmid": "42910036",
  "published": "2026-10-21",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/3hp9vqw9fgyq7.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:10Z",
      "native_id": "MED:42910036",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42910036"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2740|Pulmonary Hypertension Research and Treatments",
      "subfield": "general"
    }
  ],
  "title": "Reduction in Right Ventricular Stroke Work Index After Balloon Pulmonary Angioplasty is Associated With Long-Term Prognosis in Chronic Thromboembolic Pulmonary Hypertension.",
  "title_text": "Reduction in Right Ventricular Stroke Work Index After Balloon Pulmonary Angioplasty is Associated With Long-Term Prognosis in Chronic Thromboembolic Pulmonary Hypertension.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:10Z",
  "url": "https://research.draconitic.com/paper/3hp9vqw9fgyq7",
  "venue": "Pulmonary circulation",
  "versions": []
}