{
  "abstract": "Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a major healthcare threat, and carbapenemase genotype may influence ceftazidime–avibactam (CZA) susceptibility. This study evaluated the association between carbapenemase gene profiles and CZA resistance in CRKP isolates. In this retrospective laboratory-based study, 184 CRKP isolates (92 CZA-susceptible and 92 CZA-resistant) were analyzed. Carbapenemase genes were detected by multiplex real-time PCR, and gene distributions and profiles were compared according to CZA susceptibility. NDM was detected in 82.6% of CZA-resistant isolates but in none of the susceptible isolates (q < 0.001). All CZA-susceptible isolates carried a single carbapenemase gene, whereas 68.5% of resistant isolates carried two or more genes. NDM + OXA-48-like was the predominant profile among resistant isolates (63.0%), while OXA-48-like alone predominated among susceptible isolates (92.4%) (both q < 0.001). NDM showed 82.6% sensitivity and 100% specificity for discriminating CZA resistance, with an AUC of 0.913. Amikacin resistance was also higher among CZA-resistant isolates (60.9% vs. 31.5%; q < 0.001). NDM, particularly when co-occurring with OXA-48-like, was strongly associated with CZA resistance. Rapid carbapenemase genotyping may complement phenotypic susceptibility testing and support antimicrobial treatment decisions.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Medical Microbiology, University of Health Science Ankara Etlik City Hospital, Ankara 06170, Türkiye"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Elif Tuğçe Güner",
      "orcid": "0000-0002-8832-2201"
    },
    {
      "affs": [
        0
      ],
      "name": "Ayfer Bakır",
      "orcid": "0000-0002-9006-5267"
    },
    {
      "affs": [
        0
      ],
      "name": "Cemal Çiçek"
    },
    {
      "affs": [
        0
      ],
      "name": "Murat Aral",
      "orcid": "0000-0002-3576-4380"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3ja5e4ygyvfvj.bib",
  "cited_by": 0,
  "doi": "10.3390/ijms27209386",
  "fulltext_url": null,
  "id": "3ja5e4ygyvfvj",
  "issns": [
    "1422-0067"
  ],
  "landing_url": "https://www.mdpi.com/1422-0067/27/20/9386",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1313|Antibiotic Resistance in Bacteria"
    ]
  ],
  "openalex": "W7223397238",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-21",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/3ja5e4ygyvfvj.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:57Z",
      "native_id": "10.3390/ijms27209386",
      "source": "crossref",
      "url": "https://www.mdpi.com/1422-0067/27/20/9386"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:1313|Antibiotic Resistance in Bacteria",
      "subfield": "general"
    }
  ],
  "title": "Association of Carbapenemase Gene Profiles with Ceftazidime–avibactam Resistance in Carbapenem-Resistant Klebsiella pneumoniae",
  "title_text": "Association of Carbapenemase Gene Profiles with Ceftazidime–avibactam Resistance in Carbapenem-Resistant Klebsiella pneumoniae",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:57Z",
  "url": "https://research.draconitic.com/paper/3ja5e4ygyvfvj",
  "venue": "International Journal of Molecular Sciences",
  "versions": []
}