{
  "abstract": "Gaucher disease and Parkinson’s disease are characterized by β-glucocerebrosidase (GCase) dysfunction and increased oxidative stress. Here, we report two multifunctional hybrids that combine an iminosugar-based pharmacological chaperone scaffold with curcumin- or ferulic acid-derived antioxidant motifs. The curcumin-iminosugar hybrid 2 exhibits pH-dependent GCase modulation, enhanced GCase activity under lysosomal conditions, enhanced enzyme activity in L444P Gaucher and wild-type fibroblasts, and reduced intracellular reactive oxygen species (ROS) levels. By integrating GCase enhancement and redox modulation within a single molecular framework, compound 2 represents a promising lead for Gaucher disease and GCase-related synucleinopathies.",
  "abstract_shown": true,
  "affiliations": [
    "University of Florence , , Via della Lastruccia 3−13 , ,",
    "Meyer Children’s Hospital IRCCS , , Viale Pieraccini 24 , ,",
    "University of Florence , , Viale Pieraccini 24 , ,",
    "University of Florence , , Viale Morgagni 50 ,"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Alessio Morano"
    },
    {
      "affs": [
        0
      ],
      "name": "Camilla Matassini",
      "orcid": "0000-0002-8336-383X"
    },
    {
      "affs": [
        0
      ],
      "name": "Francesca Cardona",
      "orcid": "0000-0002-6766-4624"
    },
    {
      "affs": [
        0
      ],
      "name": "Damiano Tanini",
      "orcid": "0000-0001-8930-3566"
    },
    {
      "affs": [
        1
      ],
      "name": "Silvia Falliano"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Amelia Morrone",
      "orcid": "0000-0003-2890-8179"
    },
    {
      "affs": [
        3
      ],
      "name": "Rebecca Sodano",
      "orcid": "0009-0005-7819-1796"
    },
    {
      "affs": [
        3
      ],
      "name": "Paolo Paoli",
      "orcid": "0000-0001-6448-7266"
    },
    {
      "affs": [
        0
      ],
      "name": "Andrea Goti",
      "orcid": "0000-0002-1081-533X"
    },
    {
      "affs": [
        0
      ],
      "name": "Francesca Clemente",
      "orcid": "0000-0002-9899-0836"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3jdk16eyqbxw1.bib",
  "cited_by": 1,
  "doi": "10.1021/acsomega.6c08401",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13670301/?tool=EBI",
  "id": "3jdk16eyqbxw1",
  "issns": [
    "2470-1343"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13670301",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2737|Lysosomal Storage Disorders Research"
    ]
  ],
  "openalex": "W7215087224",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13670301/pdf/?tool=EBI",
  "pmcid": "PMC13670301",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/3jdk16eyqbxw1.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:18Z",
      "native_id": "PMC:PMC13670301",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13670301"
    },
    {
      "first_seen": "2026-10-30T12:18:39Z",
      "native_id": "10.1021/acsomega.6c08401",
      "source": "crossref",
      "url": "https://pubs.acs.org/acsodf/article/11/40/62107/5443539/A-pH-Dependent-Curcumin-Iminosugar-Hybrid-Promotes"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2737|Lysosomal Storage Disorders Research",
      "subfield": "physiology"
    }
  ],
  "title": "A pH-Dependent Curcumin–Iminosugar Hybrid Promotes GCase Enhancement and Reactive Oxygen Species Reduction",
  "title_text": "A pH-Dependent Curcumin–Iminosugar Hybrid Promotes GCase Enhancement and Reactive Oxygen Species Reduction",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:39Z",
  "url": "https://research.draconitic.com/paper/3jdk16eyqbxw1",
  "venue": "ACS omega",
  "versions": []
}