{
  "abstract": "The English national shingles vaccination programme was officially launched on 1 September 2013 using the live attenuated herpes zoster vaccine Zostavax and updated on 1 September 2023 to replace Zostavax with the two-dose, non-live, recombinant subunit herpes zoster vaccine Shingrix. A study using a regression discontinuity design, conducted following the introduction of the herpes zoster vaccination programme on 1 September 2013 in Wales and using the SAIL databank to analyse Welsh routinely collected data, suggested that Zostavax vaccination reduced the probability of a new dementia diagnosis by approximately 20% over a seven-year follow-up period. The effects of Zostavax and Shingrix on incident dementia in England have not been published to date. This protocol describes a regression discontinuity study to study the effect of herpes zoster vaccines on incident dementia in England using linked electronic health records from OpenSAFELY.",
  "abstract_shown": true,
  "affiliations": [
    "University of Bristol"
  ],
  "article_type": "PUBLISHAHEADOFPRINT",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "V. Walker"
    },
    {
      "name": "A. L. Schaffer"
    },
    {
      "name": "W. J. Hulme"
    },
    {
      "name": "C. Wood"
    },
    {
      "name": "A. Tamborska"
    },
    {
      "affs": [
        0
      ],
      "name": "A. J. Walker"
    },
    {
      "name": "B. MacKenna"
    },
    {
      "name": "B. Goldacre"
    },
    {
      "name": "J. A. C. Sterne"
    },
    {
      "name": "P. A. C. Geldsetzer"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3jge2cm3bhjhs.bib",
  "cited_by": 1,
  "doi": "10.64898/2026.09.03.26362052",
  "fulltext_url": "https://www.medrxiv.org/content/10.64898/2026.09.03.26362052v1.full",
  "id": "3jge2cm3bhjhs",
  "issns": [],
  "landing_url": "https://www.medrxiv.org/content/10.64898/2026.09.03.26362052v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "medrxiv",
      "epidemiology"
    ],
    [
      "openalex",
      "2713|Herpesvirus Infections and Treatments"
    ]
  ],
  "openalex": "W7211968281",
  "pdf_url": "https://www.medrxiv.org/content/10.64898/2026.09.03.26362052v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-03",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/3jge2cm3bhjhs.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:58Z",
      "native_id": "10.64898/2026.09.03.26362052",
      "source": "medrxiv",
      "url": "https://www.medrxiv.org/content/10.64898/2026.09.03.26362052v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "medrxiv:epidemiology",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "The effect of herpes zoster vaccines on incident dementia in England: Protocol for an OpenSAFELY regression discontinuity study",
  "title_text": "The effect of herpes zoster vaccines on incident dementia in England: Protocol for an OpenSAFELY regression discontinuity study",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:58Z",
  "url": "https://research.draconitic.com/paper/3jge2cm3bhjhs",
  "venue": "medRxiv",
  "versions": []
}