{
  "abstract": "Synthetic transmembrane ion transporters are traditionally classified as either ion channels or carriers. Here we introduce a new nanoparticle-based transporter architecture in which spherical gold nanoparticles densely decorated with flexible urea- and thiourea-based ion-binding arms efficiently mediate transmembrane anion transport, providing the first proof of principle for nanoparticle-based transmembrane anion transport. Molecular dynamics simulations reveal a dynamic relay mechanism in which chloride ions migrate across the membrane by successive hopping between flexible ion-binding arms, while thermal rotational motion of the nanoparticle further facilitates translocation by repeatedly dragging these arms between the aqueous phase and the membrane interior. These findings introduce a new design principle for the construction of synthetic ion transporters based on densely functionalized multivalent nanoparticles.",
  "abstract_shown": true,
  "affiliations": [
    "Faculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, Żwirki i Wigury 101, Warszawa, Poland, 02-089",
    "Physics Department, University of Genoa, Via Dodecaneso 33, Genoa, Italy, 16146",
    "INFN sezione di Genova, Via Dodecaneso 33, Genoa, Italy, 16146"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Meenakshi Pahwa"
    },
    {
      "affs": [
        0
      ],
      "name": "Debashis Mondal"
    },
    {
      "affs": [
        1
      ],
      "name": "Julia Blandine Bassila"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Davide Bochicchio"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Giulia Rossi"
    },
    {
      "affs": [
        0
      ],
      "name": "Michał J. Chmielewski",
      "orcid": "0000-0002-3703-7670"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3jpd0j78h3bzc.bib",
  "cited_by": 0,
  "doi": "10.26434/chemrxiv.15009372/v1",
  "fulltext_url": null,
  "id": "3jpd0j78h3bzc",
  "issns": [],
  "landing_url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009372/v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2204|Nanopore and Nanochannel Transport Studies"
    ]
  ],
  "openalex": "W7214080492",
  "pdf_url": "https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15009372/v1",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-23",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/3jpd0j78h3bzc.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:21Z",
      "native_id": "10.26434/chemrxiv.15009372",
      "source": "chemrxiv",
      "url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009372/v1"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "source:chemrxiv",
      "subfield": "general"
    }
  ],
  "title": "Engineering Gold Nanoparticles for Transmembrane Anion Transport",
  "title_text": "Engineering Gold Nanoparticles for Transmembrane Anion Transport",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:21Z",
  "url": "https://research.draconitic.com/paper/3jpd0j78h3bzc",
  "venue": "ChemRxiv",
  "versions": []
}