{
  "abstract": "Heat stroke is a life-threatening heat-related emergency that often leads to multiple organ dysfunction syndrome (MODS), with liver injury among its most prominent manifestations. HS-associated acute liver injury (HS-ALI) is a major determinant of prognosis, yet its pathogenesis remains incompletely understood. Current evidence suggests that HS-ALI results from the interplay of direct thermal stress, systemic inflammation, oxidative imbalance, coagulation dysfunction, and regulated cell death. Emerging experimental studies have implicated pyroptosis, ferroptosis, necroptosis, and gut–liver immune crosstalk in HS-associated tissue injury; however, the strength of evidence varies considerably among these mechanisms, and direct validation in human HS-ALI remains limited. Accordingly, these pathways should be considered potential contributors to disease progression rather than uniformly established mechanisms.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Clinical Laboratory, Shandong Provincial Hospital Affiliated to Shandong First Medical University",
    "Department of Oncology, Shandong Provincial Third Hospital, Shandong University"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ning Li"
    },
    {
      "affs": [
        1
      ],
      "name": "Sujing Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Xinyu Hu"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiaoqing Wu"
    },
    {
      "affs": [
        0
      ],
      "name": "Mengna Song"
    },
    {
      "affs": [
        0
      ],
      "name": "Fang Luan"
    },
    {
      "affs": [
        0
      ],
      "name": "Youyong Tang"
    },
    {
      "affs": [
        0
      ],
      "name": "Yong Wang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3jq4bzh7bwamz.bib",
  "cited_by": 0,
  "doi": "10.3389/fimmu.2026.1864759",
  "fulltext_url": null,
  "id": "3jq4bzh7bwamz",
  "issns": [
    "1664-3224"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1864759/full",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-30",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/3jq4bzh7bwamz.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:59Z",
      "native_id": "10.3389/fimmu.2026.1864759",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1864759/full"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "issn:1664-3224",
      "subfield": "immunology"
    }
  ],
  "title": "Heat stroke–induced liver injury: mechanistic insights, immune dynamics, and emerging therapeutic targets",
  "title_text": "Heat stroke–induced liver injury: mechanistic insights, immune dynamics, and emerging therapeutic targets",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T00:20:56Z",
  "url": "https://research.draconitic.com/paper/3jq4bzh7bwamz",
  "venue": "Frontiers in Immunology",
  "versions": []
}