{
  "abstract": "Local heterogeneity of ATP levels within a heteroplasmic yeast zygote: A widefield fluorescence microscopy image of a heteroplasmic Saccharomyces cerevisiae zygote with its emerging daughter cell, expressing the mitochondrially targeted ratiometric ATP sensor mtQUEEN-2m, displayed as the pixel-wise 400 nm/480 nm excitation ratio. The wild-type parental cell was identified by cell-wall staining with concanavalin A–Alexa 633 prior to mating with a partner carrying mutant mtDNA. Although the parental mitochondrial networks fuse, ATP levels remain locally higher in the wild-type-derived network, suggesting that mitochondrial bioenergetics are not fully equilibrated and may locally reflect the quality of the underlying mitochondrial genome. Thoma et al. 2026",
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  "article_type": "Issue Image",
  "arxiv": null,
  "author_total": 0,
  "authors": [],
  "bibtex": "https://research.draconitic.com/paper/3jswkh7vdqh5m.bib",
  "cited_by": 0,
  "doi": "10.1371/image.pgen.v22.i01",
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  "landing_url": "https://doi.org/10.1371/image.pgen.v22.i01",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "journal",
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  "native_subjects": [
    [
      "plos",
      "/Biology and life sciences/Biochemistry/Bioenergetics/Energy-producing organelles/Mitochondria"
    ],
    [
      "plos",
      "/Biology and life sciences/Biochemistry/Nucleic acids/DNA/Forms of DNA/Mitochondrial DNA"
    ],
    [
      "plos",
      "/Biology and life sciences/Cell biology/Cellular structures and organelles/Energy-producing organelles/Mitochondria"
    ],
    [
      "plos",
      "/Biology and life sciences/Cell biology/Cellular types/Animal cells/Germ cells/Ova/Zygotes"
    ],
    [
      "plos",
      "/Biology and life sciences/Genetics/DNA/Forms of DNA/Mitochondrial DNA"
    ],
    [
      "plos",
      "/Biology and life sciences/Genetics/Genomics"
    ],
    [
      "plos",
      "/Biology and life sciences/Organisms/Eukaryota/Fungi/Yeast"
    ],
    [
      "plos",
      "/Biology and life sciences/Organisms/Eukaryota/Fungi/Yeast/Saccharomyces/Saccharomyces cerevisiae"
    ],
    [
      "plos",
      "/Research and analysis methods/Animal studies/Experimental organism systems/Model organisms/Saccharomyces cerevisiae"
    ],
    [
      "plos",
      "/Research and analysis methods/Animal studies/Experimental organism systems/Yeast and fungal models/Saccharomyces cerevisiae"
    ],
    [
      "plos",
      "/Research and analysis methods/Imaging techniques/Fluorescence imaging"
    ],
    [
      "plos",
      "/Research and analysis methods/Microscopy/Light microscopy/Fluorescence microscopy"
    ],
    [
      "plos",
      "/Research and analysis methods/Model organisms/Saccharomyces cerevisiae"
    ]
  ],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-27",
  "publisher": "Public Library of Science",
  "ris": "https://research.draconitic.com/paper/3jswkh7vdqh5m.ris",
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    {
      "first_seen": "2026-10-30T12:17:17Z",
      "native_id": "10.1371/image.pgen.v22.i01",
      "source": "plos",
      "url": "https://doi.org/10.1371/image.pgen.v22.i01"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "plos:cell biology",
      "subfield": "cell-biology"
    },
    {
      "field": "biology",
      "origin": "plos:genetics",
      "subfield": "genetics-genomics"
    }
  ],
  "title": "PLoS Genetics Issue Image | Vol. 22(1) October 2026",
  "title_text": "PLoS Genetics Issue Image | Vol. 22(1) October 2026",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:17Z",
  "url": "https://research.draconitic.com/paper/3jswkh7vdqh5m",
  "venue": "PLoS Genetics",
  "versions": []
}