{
  "abstract": "Diabetic peripheral neuropathy (DPN) is characterized by progressive and symmetrical sensory alterations and constitutes one of the earliest and main complications of diabetes. Several mouse models have been developed to mimic the pathogenesis of DPN with some discrepancies to fully recapitulate the human disease. In the present study, we aimed to characterize the onset and progression of peripheral neuropathy in mice fed with 45% kcal High Fat Diet (HFD) for 16 weeks. Our data show that mice fed with this diet developed obesity, dyslipidemia, hyperglycemia, impaired glucose tolerance and insulin resistance. Using sensory tests, we found that HFD-fed mice developed mechanical hypoalgesia and thermal hyperalgesia starting after 12 weeks of diet. Our analysis of glabrous foot skin innervation revealed a decrease in intraepidermal nerve fiber density (IENFD) associated with a significant reduction of nociceptive Schwann cells (nSCs) in neuropathic mice after 16 weeks of HFD. Overall, this study shows that mice fed with a 45% kcal HFD recapitulate the main metabolic, behavioral and anatomical changes generally observed in patients with DPN and represent a reliable model to study the pathogenesis of the disease.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "Research Article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "name": "Guillaume Rastoldo"
    },
    {
      "name": "Alexis Chirpaz"
    },
    {
      "name": "Sarrah Tréport"
    },
    {
      "name": "Anne-Yael Gamin"
    },
    {
      "name": "Ali Jaafar"
    },
    {
      "name": "Aurélie Paulo-Ramos"
    },
    {
      "name": "Thomas Sandaye"
    },
    {
      "name": "Katy Thouvenot"
    },
    {
      "name": "Matthieu Bringart"
    },
    {
      "name": "Marie-Paule Gonthier"
    },
    {
      "name": "Gilles Lambert"
    },
    {
      "name": "Steeve Bourane"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3jty714p9ag12.bib",
  "cited_by": 0,
  "doi": "10.1371/journal.pone.0356285",
  "fulltext_url": null,
  "id": "3jty714p9ag12",
  "issns": [
    "1932-6203",
    "1932-6203"
  ],
  "landing_url": "https://hal.science/hal-05739407v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
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    [
      "plos",
      "/Biology and life sciences/Cell biology/Cellular types/Animal cells/Glial cells/Macroglial cells/Schwann cells"
    ],
    [
      "plos",
      "/Biology and life sciences/Cell biology/Cellular types/Animal cells/Neurons"
    ],
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      "/Biology and life sciences/Cell biology/Cellular types/Animal cells/Neurons/Nerve fibers"
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      "plos",
      "/Biology and life sciences/Neuroscience/Sensory perception"
    ],
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      "plos",
      "/Biology and life sciences/Nutrition/Diet"
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    [
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      "/Biology and life sciences/Psychology/Cognitive psychology/Perception/Sensory perception"
    ],
    [
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      "/Medicine and health sciences/Endocrinology/Endocrine disorders/Diabetes mellitus"
    ],
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      "plos",
      "/Medicine and health sciences/Medical conditions/Metabolic disorders/Diabetes mellitus"
    ],
    [
      "plos",
      "/Medicine and health sciences/Medical conditions/Neuropathy/Peripheral neuropathy"
    ],
    [
      "plos",
      "/Medicine and health sciences/Neurology/Neuropathy/Peripheral neuropathy"
    ],
    [
      "plos",
      "/Medicine and health sciences/Nutrition/Diet"
    ],
    [
      "plos",
      "/Research and analysis methods/Animal studies/Experimental organism systems/Animal models/Mouse models"
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      "/Research and analysis methods/Animal studies/Experimental organism systems/Model organisms/Mouse models"
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  "pdf_url": "https://hal.science/hal-05739407/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-01",
  "publisher": "Public Library of Science",
  "ris": "https://research.draconitic.com/paper/3jty714p9ag12.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:29Z",
      "native_id": "hal-05739407",
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      "url": "https://hal.science/hal-05739407v1"
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  "subjects": [
    {
      "field": "biology",
      "origin": "plos:cell biology",
      "subfield": "cell-biology"
    },
    {
      "field": "biology",
      "origin": "plos:neuroscience",
      "subfield": "neuroscience"
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    {
      "field": "medicine",
      "origin": "plos:nutrition",
      "subfield": "nutrition"
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  "title": "Characterization of diabetic peripheral neuropathy in a high-fat diet mouse model",
  "title_text": "Characterization of diabetic peripheral neuropathy in a high-fat diet mouse model",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:02Z",
  "url": "https://research.draconitic.com/paper/3jty714p9ag12",
  "venue": "PLoS ONE",
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}