{
  "abstract": "Skin photoaging, primarily driven by ultraviolet B (UVB) radiation, is a complex process involving oxidative stress and autophagic dysfunction, for which effective therapeutic options remain limited. Here, we identified a novel peptide, OA-AL14 (ALFWPMKKPWPESC), from the skin secretions of the frog Odorrana andersonii Boulenger, 1882, and investigated its protective effects against UVB-induced photoaging. OA-AL14 exhibited excellent biocompatibility and potent antioxidant activity in vitro. In a UVB-irradiated mouse model, topical application of OA-AL14 significantly ameliorated key features of photoaging, including erythema, pigmentation, epidermal hyperplasia, and barrier disruption. Mechanistically, OA-AL14 activated the Nrf2 antioxidant pathway and restored cellular redox balance. Furthermore, transcriptomic and biochemical analyses revealed that OA-AL14 induced protective autophagy via the AMPK/mTOR signaling pathway. Inhibition of autophagy partially abrogated its protective effects, confirming the functional relevance of this mechanism. These findings establish OA-AL14 as a promising multifunctional candidate for treating skin photoaging by integrating antioxidant defense and autophagy activation.",
  "abstract_shown": true,
  "affiliations": [
    "Key Laboratory of Skin and Mucosal Injury Repair, Regeneration & Active Peptides of Yunnan Provincial Department of Education, Regenerative Medicine Research Center, Faculty of Basic Medical Science Kunming Medical University Kunming Yunnan China",
    "Department of Pharmacology, Faculty of Basic Medical Science Kunming Medical University Kunming Yunnan China",
    "Yunnan Characteristic Plant Extraction Laboratory Co., Ltd. Yunnan China",
    "Key Laboratory of Chemistry in Ethnic Medicinal Resources & Key Laboratory of Natural Products Synthetic Biology of Ethnic Medicinal Endophytes, State Ethnic Affairs Commission & Ministry of Education, School of Ethnic Medicine Yunnan Minzu University Kunming Yunnan China"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 17,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ying Peng"
    },
    {
      "affs": [
        0
      ],
      "name": "Yu Wu",
      "orcid": "0000-0001-8176-7059"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhe Fu"
    },
    {
      "affs": [
        0
      ],
      "name": "Zijian Kang"
    },
    {
      "affs": [
        0
      ],
      "name": "Qiuye Jia",
      "orcid": "0000-0003-1761-7827"
    },
    {
      "affs": [
        0
      ],
      "name": "Wenbi Zhao",
      "orcid": "0000-0003-0910-1417"
    },
    {
      "affs": [
        0
      ],
      "name": "Z P Wang",
      "orcid": "0009-0006-2819-4662"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuexi Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Ruijie Zhang"
    },
    {
      "affs": [
        1,
        0
      ],
      "name": "Y F Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Zeqiong Ru"
    },
    {
      "affs": [
        2
      ],
      "name": "Wenrou Su"
    },
    {
      "affs": [
        0
      ],
      "name": "Naixin Liu"
    },
    {
      "affs": [
        1,
        0
      ],
      "name": "Yilin Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Saige Yin"
    },
    {
      "affs": [
        3
      ],
      "name": "Ying Wang"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Xinwang Yang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3k8f4def217bx.bib",
  "cited_by": 26,
  "doi": "10.1111/1749-4877.70134",
  "fulltext_url": null,
  "id": "3k8f4def217bx",
  "issns": [
    "1749-4868",
    "1749-4869",
    "1749-4877"
  ],
  "landing_url": "https://doi.org/10.1111/1749-4877.70134",
  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2708|Skin Protection and Aging"
    ]
  ],
  "openalex": "W7163523168",
  "pdf_url": null,
  "pmcid": null,
  "pmid": "42241584",
  "published": "2026-06-04",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/3k8f4def217bx.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:26:54Z",
      "native_id": "W7163523168",
      "source": "openalex",
      "url": "https://doi.org/10.1111/1749-4877.70134"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2708|Skin Protection and Aging",
      "subfield": "general"
    }
  ],
  "title": "Amphibian‐Derived Peptide OA‐AL14 Alleviates UVB‐Induced Skin Photoaging via Autophagy Activation Mediated by the AMPK/mTOR Pathway",
  "title_text": "Amphibian‐Derived Peptide OA‐AL14 Alleviates UVB‐Induced Skin Photoaging via Autophagy Activation Mediated by the AMPK/mTOR Pathway",
  "type": "peer-reviewed",
  "updated_at": "2026-11-05T13:21:05Z",
  "url": "https://research.draconitic.com/paper/3k8f4def217bx",
  "venue": "Integrative Zoology",
  "versions": []
}