{
  "abstract": null,
  "abstract_shown": false,
  "affiliations": [
    "Department of Medical Oncology, Cancer Center, Zhongshan Hospital Fudan University, Shanghai, China.",
    "Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.",
    "Department of Oncology, Zhongshan Hospital (Xiamen), Fudan University, Xiamen, China. Clinical Research Center for Precision Medicine of Abdominal Tumor of Fujian Province, Xiamen, Fujian.",
    "Caris Life Sciences, Phoenix, Arizona, USA.",
    "Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.",
    "Department of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan, USA.",
    "Gastrointestinal Cancer Research, West Cancer Center and Research Institute, Germantown, Tennessee, USA.",
    "Ruesch Center for The Cure of Gastrointestinal Cancers, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, District of Columbia, USA.",
    "Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, Minnesota, USA.",
    "Departments of Medical Oncology, Washington University in St. Louis/Siteman Cancer Center, St. Louis, Missouri, USA.",
    "University of Cincinnati, Cincinnati, Ohio, USA.",
    "Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA.",
    "Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA lenz@med.usc.edu."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 21,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Jingyuan Wang"
    },
    {
      "affs": [
        3
      ],
      "name": "Joanne Xiu"
    },
    {
      "affs": [
        3
      ],
      "name": "Alex P Farrell"
    },
    {
      "affs": [
        1
      ],
      "name": "Francesca Battaglin",
      "orcid": "0000-0002-9869-0163"
    },
    {
      "affs": [
        1
      ],
      "name": "Hiroyuki Arai",
      "orcid": "0000-0002-1886-7070"
    },
    {
      "affs": [
        4
      ],
      "name": "Yan Yang"
    },
    {
      "affs": [
        1
      ],
      "name": "Shivani Soni"
    },
    {
      "affs": [
        1
      ],
      "name": "Wu Zhang"
    },
    {
      "affs": [
        4
      ],
      "name": "Joshua Millstein"
    },
    {
      "affs": [
        5
      ],
      "name": "Anthony F Shields"
    },
    {
      "affs": [
        6
      ],
      "name": "Axel Grothey"
    },
    {
      "affs": [
        7
      ],
      "name": "Benjamin A Weinberg"
    },
    {
      "affs": [
        7
      ],
      "name": "John Marshall"
    },
    {
      "affs": [
        8
      ],
      "name": "Emil Lou",
      "orcid": "0000-0002-1607-1386"
    },
    {
      "affs": [
        9
      ],
      "name": "Moh'd Khushman",
      "orcid": "0000-0002-3095-5073"
    },
    {
      "affs": [
        10
      ],
      "name": "Davendra P S Sohal"
    },
    {
      "affs": [
        11
      ],
      "name": "Michael J Hall"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Tianshu Liu"
    },
    {
      "affs": [
        3
      ],
      "name": "Matthew James Oberley"
    },
    {
      "affs": [
        3
      ],
      "name": "David Spetzler"
    },
    {
      "affs": [
        12
      ],
      "name": "Heinz-Josef Lenz",
      "orcid": "0000-0003-2178-9568"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3m3bxn0549gna.bib",
  "cited_by": 0,
  "doi": "10.1136/jitc-2026-015933",
  "fulltext_url": "https://europepmc.org/articles/PMC13691783",
  "id": "3m3bxn0549gna",
  "issns": [
    "2051-1426"
  ],
  "landing_url": "https://europepmc.org/article/MED/42880820",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2734|Genetic factors in colorectal cancer"
    ]
  ],
  "openalex": "W7222159400",
  "pdf_url": "https://europepmc.org/articles/PMC13691783?pdf=render",
  "pmcid": "PMC13691783",
  "pmid": "42880820",
  "published": "2026-10-15",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/3m3bxn0549gna.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:46Z",
      "native_id": "MED:42880820",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42880820"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "journal-openalex:2403|Immunotherapy and Immune Responses",
      "subfield": "immunology"
    },
    {
      "field": "medicine",
      "origin": "journal-openalex:2730|Cancer Immunotherapy and Biomarkers",
      "subfield": "oncology"
    }
  ],
  "title": "Distinct genomic landscapes of mismatch-repair deficiency (dMMR)/microsatellite instability-high (MSI-H) gastrointestinal (GI) cancer depending on tumor mutation burden (TMB) levels.",
  "title_text": "Distinct genomic landscapes of mismatch-repair deficiency (dMMR)/microsatellite instability-high (MSI-H) gastrointestinal (GI) cancer depending on tumor mutation burden (TMB) levels.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:46Z",
  "url": "https://research.draconitic.com/paper/3m3bxn0549gna",
  "venue": "Journal for immunotherapy of cancer",
  "versions": []
}