{
  "abstract": "BACKGROUND: Early detection of subclinical worsening heart failure (HF) is essential to enable timely, proactive treatment that may alter the clinical course and prevent hospitalization. This study demonstrates how early non-invasive telemonitoring of respiratory stability time (RST) can detect subclinical worsening HF. METHODS AND RESULTS: Daily RST was calculated automatically from all-night respiratory signals in 66 patients. Subclinical worsening was detected by declines in RST preceding overt worsening HF in the control group (blinded to RST; n=35) and in the RST group (RST monitored daily by clinicians; n=31). The RST recovery zone sufficient to avert hospitalization was determined by RST responses to treatment escalation for overt worsening HF. Two clinically relevant RST thresholds were identified: RST <20 s, indicating a high-risk zone for subclinical worsening preceding hospitalization; and RST ≥30 s, defining a recovery target zone associated with hospitalization avoidance. The duration of subclinical worsening HF from the onset of RST decline <20 s to overt worsening was 40.0 days in the control group. In contrast, the interval from the onset of overt worsening HF to hospitalization was markedly shorter (control group, 7.5 days; RST group, 8.0 days). CONCLUSIONS: Noninvasive RST telemonitoring enables early detection of the prolonged subclinical worsening phase of HF and provides a clinically actionable biological target for proactive intervention aimed at preventing HF-related hospitalization.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "name": "Hidetsugu Asanoi"
    },
    {
      "name": "Yasushi Sakata"
    },
    {
      "name": "Koichiro Kinugawa"
    },
    {
      "name": "Hideo Fujita"
    },
    {
      "name": "Shin-ichi Momomura"
    },
    {
      "name": "Shigeru Toyota"
    },
    {
      "name": "Teruo Inoue"
    },
    {
      "name": "Takahiko Naruko"
    },
    {
      "name": "Moriaki Inoko"
    },
    {
      "name": "Tomomi Yamada"
    },
    {
      "name": "Yoshiki Sawa"
    },
    {
      "name": "Shigeru Miyagawa"
    },
    {
      "name": "on behalf of the ITMETHOD-HF-II Investigators"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3mb9yksf3vn0k.bib",
  "cited_by": 0,
  "doi": "10.1253/circj.cj-26-0227",
  "fulltext_url": "https://www.jstage.jst.go.jp/article/circj/90/11/90_CJ-26-0227/_article",
  "id": "3mb9yksf3vn0k",
  "issns": [
    "1347-4820",
    "1346-9843"
  ],
  "landing_url": "https://www.jstage.jst.go.jp/article/circj/90/11/90_CJ-26-0227/_article",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "jstage-journal",
      "medicine/cardiovascular"
    ],
    [
      "openalex",
      "2705|Heart Failure Treatment and Management"
    ]
  ],
  "openalex": "W7167476574",
  "pdf_url": "https://www.jstage.jst.go.jp/article/circj/advpub/0/advpub_CJ-26-0227/_pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-23",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/3mb9yksf3vn0k.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:24Z",
      "native_id": "10.1253/circj.cj-26-0227",
      "source": "jstage",
      "url": "https://www.jstage.jst.go.jp/article/circj/90/11/90_CJ-26-0227/_article"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Heart Failure Treatment and Management",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Early Detection of Subclinical Worsening Heart Failure Using a Respiratory Stability Telemonitoring System",
  "title_text": "Early Detection of Subclinical Worsening Heart Failure Using a Respiratory Stability Telemonitoring System",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:24Z",
  "url": "https://research.draconitic.com/paper/3mb9yksf3vn0k",
  "venue": "Circulation Journal",
  "versions": []
}