{
  "abstract": "Background: Renal denervation (RDN) has demonstrated blood pressure (BP) – lowering efficacy in resistant hypertension; however, response heterogeneity remains incompletely understood. Obesity is associated with sympathetic overactivity and may influence the BP response to RDN. We evaluated BP changes following Symplicity Spyral RDN in a real-world cohort stratified by obesity status. Methods: We conducted a retrospective single-center cohort study including patients with resistant hypertension who underwent radiofrequency RDN using the Symplicity Spyral system at Sabah Al-Ahmad Cardiac Center in Kuwait between March 2023 and August 2024. BP was assessed at baseline, immediate postprocedure, and at 6 months. The primary outcome was change in systolic and diastolic BP at 6 months and the comparison between obese and nonobese patients. Secondary outcomes included time to achieving BP targets and clinical predictors of target achievement. Results: A total of 50 patients underwent RDN (mean age: 61.7 years); 32 were obese, and 18 were nonobese. In the overall cohort, systolic BP (SBP) decreased from 163.7 ± 24.6 mmHg at baseline to 129.4 ± 13.5 mmHg at 6 months (P < 0.001), and diastolic BP decreased from 86.7 ± 16.6 mmHg to 75.9 ± 8.2 mmHg (P = 0.0004). Repeated measures analysis of covariance demonstrated significant SBP changes over time (P < 0.001) with no overall between-group difference by obesity status; however, a significant time × body mass index category interaction was observed for SBP (P = 0.038). Kaplan–Meier analysis showed a median time of 2 months to BP target achievement in both the groups. In multivariable logistic regression, dyslipidemia was independently associated with lower odds of BP target achievement (odds ratio: 0.17, 95% confidence interval: 0.03–0.80;P= 0.036). Conclusion: In this real-world cohort, Symplicity Spyral RDN was associated with significant BP reduction at 6 months in both obese and nonobese patients. Obesity status did not appear to diminish overall BP-lowering efficacy, although SBP response trajectory differed over time. In exploratory multivariable analysis, dyslipidemia was associated with lower odds of BP target achievement",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "name": "Yahya E. Alansari"
    },
    {
      "name": "Abdullah Alawadi"
    },
    {
      "name": "Budour Almandeel"
    },
    {
      "name": "Nader Alasousi"
    },
    {
      "name": "Mohammad A. Aljarallah"
    },
    {
      "name": "Ahmad Alsaber"
    },
    {
      "name": "Rajesh Rajan"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3mhjr80848sb6.bib",
  "cited_by": 0,
  "doi": "10.4103/heartviews.heartviews_169_25",
  "fulltext_url": "https://www.ovid.com/jnls/hrtv/fulltext/10.4103/heartviews.heartviews_169_25~clinical-effect-of-renal-denervation-on-resistant",
  "id": "3mhjr80848sb6",
  "issns": [
    "1995-705X",
    "0976-5123"
  ],
  "landing_url": "https://doi.org/10.4103/heartviews.heartviews_169_25",
  "language": "en",
  "licence": "CC-BY-NC-SA",
  "licence_label": "CC BY-NC-SA",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-sa/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RC666-701"
    ],
    [
      "openalex",
      "2705|Blood Pressure and Hypertension Studies"
    ]
  ],
  "openalex": "W7208743080",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-01",
  "publisher": "Wolters Kluwer Medknow Publications",
  "ris": "https://research.draconitic.com/paper/3mhjr80848sb6.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:43:58Z",
      "native_id": "a122591bafa7403b9a6189a65609557e",
      "source": "doaj",
      "url": "https://doi.org/10.4103/heartviews.heartviews_169_25"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Blood Pressure and Hypertension Studies",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Clinical Effect of Renal Denervation on Resistant Hypertension in Obese and Nonobese Patients: Insights from Kuwait",
  "title_text": "Clinical Effect of Renal Denervation on Resistant Hypertension in Obese and Nonobese Patients: Insights from Kuwait",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:43:58Z",
  "url": "https://research.draconitic.com/paper/3mhjr80848sb6",
  "venue": "Heart Views",
  "versions": []
}