{
  "abstract": "Introduction: Postmastectomy radiotherapy plays a pivotal role in improving locoregional control and survival outcomes in early as well as in advanced-stage breast cancer patients. With the transition from conventional radiotherapy techniques to advanced intensity-modulated approaches, evaluation based solely on physical dose parameters is no longer sufficient. Radiobiological modelling provides a more clinically meaningful framework by quantifying tumor control and normal tissue complications. Objectives: The objective of this prospective study was to evaluate the radiobiological differences between three radiotherapy planning techniques, namely three-dimensional conformal radiotherapy (3DCRT), field-in-field forward planned intensity modulated radiotherapy (FIF-FP-IMRT), and inversely planned intensity modulated radiotherapy (IP-IMRT) in postmastectomy breast cancer patients. Materials and Methods: The present prospective study involved 150 postmastectomy breast cancer patients who have undergone chemotherapy treatment. Each patient was planned with three radiotherapy planning techniques, namely 3DCRT, FIF-FP-IMRT, and IP-IMRT for comparative radiobiological analysis. Radiobiological parameters, namely tumor control probability (TCP) and normal tissue complication probability (NTCP), were then calculated and compared for the three planning techniques. Results: The mean TCP values were comparable among all three techniques, with no statistically significant difference. However, significant differences were observed in most of the NTCP parameters (P < 0.05). Conclusion: The present study demonstrates that advanced radiotherapy planning techniques provide significant radiobiological advantages over conventional techniques in postmastectomy breast cancer patients. Among the three evaluated techniques, IP-IMRT showed the most favorable radiobiological profile, followed by FIF-FP-IMRT, while 3DCRT showed comparatively higher NTCP.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "name": "Garima Gaur"
    },
    {
      "name": "Gurpreet Kaur"
    },
    {
      "name": "Baltej Singh"
    },
    {
      "name": "Pardeep Garg"
    },
    {
      "name": "Vinod Kumar Dangwal"
    },
    {
      "name": "Raja Paramjeet Singh Banipal"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3mq88jwdhjptx.bib",
  "cited_by": 0,
  "doi": "10.4103/jmp.jmp_106_26",
  "fulltext_url": "https://www.ovid.com/jnls/jomp/fulltext/10.4103/jmp.jmp_106_26~comparative-radiobiological-evaluation-of-radiotherapy",
  "id": "3mq88jwdhjptx",
  "issns": [
    "0971-6203",
    "1998-3913"
  ],
  "landing_url": "https://doi.org/10.4103/jmp.jmp_106_26",
  "language": "en",
  "licence": "CC-BY-NC-SA",
  "licence_label": "CC BY-NC-SA",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-sa/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "R895-920"
    ],
    [
      "openalex",
      "3108|Advanced Radiotherapy Techniques"
    ]
  ],
  "openalex": "W7214113647",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-07-01",
  "publisher": "Wolters Kluwer Medknow Publications",
  "ris": "https://research.draconitic.com/paper/3mq88jwdhjptx.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:43:59Z",
      "native_id": "c461d6689f9f47d6bacd03b6e7136ad8",
      "source": "doaj",
      "url": "https://doi.org/10.4103/jmp.jmp_106_26"
    }
  ],
  "subjects": [
    {
      "field": "physics",
      "origin": "openalex:3108|Advanced Radiotherapy Techniques",
      "subfield": "applied-instrumentation"
    }
  ],
  "title": "Comparative Radiobiological Evaluation of Radiotherapy Techniques Using Equivalent Uniform Dose, Tumor Control Probability, and Normal Tissue Complication Probability in Postmastectomy Breast Cancer",
  "title_text": "Comparative Radiobiological Evaluation of Radiotherapy Techniques Using Equivalent Uniform Dose, Tumor Control Probability, and Normal Tissue Complication Probability in Postmastectomy Breast Cancer",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:43:59Z",
  "url": "https://research.draconitic.com/paper/3mq88jwdhjptx",
  "venue": "Journal of Medical Physics",
  "versions": []
}