{
  "abstract": "Infection is a leading cause of mortality in patients with chronic kidney disease (CKD), in which T cell dysfunction is considered a typical feature. Although platelets are active participants in immune response, their role in regulating T cell function in patients with CKD remains unclear. In this study, we demonstrate that CD8+ T cell senescence may be a major contributor to the immunosuppressed state of patients with CKD, and that platelets derived from patients with CKD can induce premature CD8+ T cell senescence, potentially through mediating mitochondrial dysfunction. Further investigations reveal that platelet-derived microparticles (PMPs) from patients with CKD promote CD8+ T cell senescence via transferring miR-550a-5p, thereby decreasing PMPCB expression and inducing NDUFS8 cleavage failure. Finally, inhibition of miR-550a-5p and pretreatment with nicotinamide mononucleotide are capable of preventing platelet-induced CD8+ T cell senescence in CKD patients. Collectively, these findings suggest that the ectopic transient expression of platelet-derived miR-550a-5p in CD8+ T cells promotes cellular senescence by regulating the PMPCB–NDUFS8 axis, which can be exploited to treat CKD-associated immunosenescence.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Nephrology, Chongqing Key Laboratory of Prevention and Treatment of Kidney Disease, Chongqing Clinical Research Center of Kidney and Urology Diseases, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing, 400037 China",
    "Department of Nephrology, General Hospital of Western Theater Command, PLA, Chengdu, China",
    "State Key Laboratory of Trauma and Chemical Poisoning, Institute of Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Army Medical University (Third Military Medical University), Chongqing, 400038 China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Yuewen Sun"
    },
    {
      "affs": [
        0
      ],
      "name": "Qigang Lan"
    },
    {
      "affs": [
        0
      ],
      "name": "Yaqin Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Minhua Xie"
    },
    {
      "affs": [
        0
      ],
      "name": "Xinyi Wu"
    },
    {
      "affs": [
        0
      ],
      "name": "Liangjing Lv"
    },
    {
      "affs": [
        0
      ],
      "name": "Qing Xin"
    },
    {
      "affs": [
        2
      ],
      "name": "Jun Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiaoyi Zhong"
    },
    {
      "affs": [
        0
      ],
      "name": "Mengying Yao"
    },
    {
      "affs": [
        0
      ],
      "name": "Shuiqin Gong"
    },
    {
      "affs": [
        0
      ],
      "name": "Siyan Zhou"
    },
    {
      "affs": [
        2
      ],
      "name": "Junping Wang",
      "orcid": "0000-0001-5905-0940"
    },
    {
      "affs": [
        0
      ],
      "name": "Jinghong Zhao",
      "orcid": "0000-0001-9750-3285"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3mqjzn7tex6fd.bib",
  "cited_by": 0,
  "doi": "10.1038/s12276-026-01876-z",
  "fulltext_url": "https://doi.org/10.1038/s12276-026-01876-z",
  "id": "3mqjzn7tex6fd",
  "issns": [
    "2092-6413",
    "1226-3613"
  ],
  "landing_url": "https://doi.org/10.1038/s12276-026-01876-z",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
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      "lcc",
      "QD415-436"
    ],
    [
      "lcc",
      "R"
    ],
    [
      "openalex",
      "1307|Telomeres, Telomerase, and Senescence"
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  "openalex": "W7125696421",
  "pdf_url": "https://www.nature.com/articles/s12276-026-01876-z.pdf",
  "pmcid": "PMC13737140",
  "pmid": "42888218",
  "published": "2026-10-01",
  "publisher": "Nature Publishing Group",
  "ris": "https://research.draconitic.com/paper/3mqjzn7tex6fd.ris",
  "sources": [
    {
      "first_seen": "2026-11-08T14:20:53Z",
      "native_id": "106da83244e8473bb862fba79b071230",
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      "url": "https://doi.org/10.1038/s12276-026-01876-z"
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    {
      "first_seen": "2026-11-09T12:22:25Z",
      "native_id": "PMC13737140",
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  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1307|Telomeres, Telomerase, and Senescence",
      "subfield": "cell-biology"
    }
  ],
  "title": "Platelet-derived microparticles induce CD8+ T cell senescence in chronic kidney disease via the transfer of microRNA-550a-5p",
  "title_text": "Platelet-derived microparticles induce CD8+ T cell senescence in chronic kidney disease via the transfer of microRNA-550a-5p",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T14:21:13Z",
  "url": "https://research.draconitic.com/paper/3mqjzn7tex6fd",
  "venue": "Experimental and Molecular Medicine",
  "versions": []
}