{
  "abstract": "Objective: This study aimed to investigate, using clinical serum metabolomics, the effects of general anesthesia combined with transversus abdominis plane block (TAPB) on systemic metabolism in patients undergoing radical gastrectomy compared with general anesthesia alone.\n\nMethods: Fifty-six patients undergoing laparoscopic-assisted radical gastrectomy for gastric cancer were assigned to a general anesthesia–only group (control group, 30 patients) and a general anesthesia combined with TAPB group (treatment group, 26 patients). Clinical serum metabolomics analyses were performed to investigate alterations in systemic metabolism between the control and treatment groups.\n\nResults: Kyoto Encyclopedia of Genes and Genomes analysis revealed that the top differential metabolic pathways between the treatment and control groups were choline metabolism in cancer, glycerophospholipid metabolism, adenosine triphosphate–binding cassette transporters, and protein digestion and absorption. In this study, altered choline metabolism in cancer and glycerophospholipid metabolism shared the same five metabolites, including 1-stearoyl-2-arachidonyl-sn-glycero-3-phosphocholine, 1-stearoyl-2-oleoyl-sn-glycerol 3-phosphocholine, phosphocholine, 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (PC (16:0/16:0)), and glycerophosphocholine. The levels of these metabolites were decreased with TAPB. General anesthesia combined with TAPB reduced choline and glycerophospholipid metabolism and may serve as a potential indicator. In addition, DL-proline, lysine, DL-glutamic acid, and glutamic acid were shared with adenosine triphosphate–binding cassette transporters and protein digestion and absorption. Their decreased levels in TAPB contributed to the beneficial effects of anesthesia.\n\nConclusions: General anesthesia combined with TAPB treatment reduced sufentanil dose and pain scores (numeric rating scale and visual analog scale) on postoperative days 1 and 3 compared with the control during laparoscopic-assisted radical gastrectomy. Furthermore, majority of the top differential metabolites were associated with indicators of anesthesia management and may have contributed to the beneficial effects of combined anesthesia. These metabolites included prostaglandins and sucrose, which may have contributed to the effects of anesthesia, including TAPB.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Anesthesiology, Affiliated Hospital of Putian University, China",
    "Department of Gastroenterology, Affiliated Hospital of Putian University, China",
    "Department of Anesthesiology, The First Hospital of Putian, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Xiao Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Xinqiang Lin"
    },
    {
      "affs": [
        0
      ],
      "name": "Qiqi Li"
    },
    {
      "affs": [
        1
      ],
      "name": "Xiantu Qiu"
    },
    {
      "affs": [
        2
      ],
      "name": "Jiafeng Lin",
      "orcid": "0009-0004-6451-2301"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3mrmsg880jq4j.bib",
  "cited_by": 0,
  "doi": "10.1177/03000605261489359",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13735680/",
  "id": "3mrmsg880jq4j",
  "issns": [
    "0300-0605",
    "1473-2300"
  ],
  "landing_url": "https://doi.org/10.1177/03000605261489359",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Observational Study"
    ],
    [
      "openalex",
      "2703|Anesthesia and Pain Management"
    ]
  ],
  "openalex": "W7214550063",
  "pdf_url": null,
  "pmcid": "PMC13735680",
  "pmid": "42802220",
  "published": "2026-09-27",
  "publisher": "SAGE Publications",
  "ris": "https://research.draconitic.com/paper/3mrmsg880jq4j.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:21:19Z",
      "native_id": "PMC13735680",
      "source": "pmc",
      "url": "https://doi.org/10.1177/03000605261489359"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2703|Anesthesia and Pain Management",
      "subfield": "surgery"
    }
  ],
  "title": "Untargeted serum metabolomic profiling reveals altered choline-phospholipid and amino acid metabolism in patients receiving subcostal transversus abdominis plane block combined with general anesthesia for radical gastrectomy: A prospective comparative study",
  "title_text": "Untargeted serum metabolomic profiling reveals altered choline-phospholipid and amino acid metabolism in patients receiving subcostal transversus abdominis plane block combined with general anesthesia for radical gastrectomy: A prospective comparative study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:21:19Z",
  "url": "https://research.draconitic.com/paper/3mrmsg880jq4j",
  "venue": "The Journal of International Medical Research",
  "versions": []
}