{
  "abstract": "The purpose of this study was to investigate the effects of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on cardiac function and myocardial work (MW) in women with obesity. Twenty-five women with obesity (Age: 28 ± 5 years, BMI: 35.03 ± 3.19 kg/m²) were randomized to 8 weeks of either HIIT (n = 11, 4×4-min at 85–95% of HRmax) or MICT (n = 14, 41-min at 65–75% of HRmax). Cardiac function and strains were evaluated using two-dimensional speckle tracking echocardiography. MW indices were computed via dedicated software. HIIT significantly improved myocardial efficiency, as evidenced by a reduction in global wasted work (GWW [d = 0.64, p = 0.042]) and an increase global work efficiency (GWE [d = 0.83, p = 0.005]). Both HIIT and MICT reduced left ventricular global longitudinal strain (GLS, p = 0.017 for HIIT; p = 0.023 for MICT), left atrial (LA) contraction (p < 0.001 for both), LA conduit (p = 0.002 for both), LA reservoir (p = 0.003 for HIIT; p < 0.001 for MICT), and LA stiffness (p = 0.004 for HIIT, p = 0.031 for MICT). HIIT and MICT both improved myocardial deformation in women with obesity. However, only HIIT improved myocardial efficiency, suggesting a potential superiority for targeting subclinical cardiac dysfunction in this population.",
  "abstract_shown": true,
  "affiliations": [
    "Research Group on Systemic Arterial Hypertension, Arterial Stiffness and Vascular Aging, Maringa, Brazil",
    "Cesumar University, Maringa, Brazil",
    "Department of Physical Education, State University of Maringa, Maringa, Brazil",
    "School of Human Sciences (Sport Science, Exercise and Health), The University of Western Australia, Perth, WA Australia",
    "Department of Medicine, State University of Maringa, Maringa, Brazil",
    "Diabetes Research Centre, College of Life Sciences, University of Leicester, Leicester, UK",
    "Department of Cardiology, St George’s University Hospitals NHS Foundation Trust,, London, UK",
    "Faculty of Sport, University of Porto, Porto, Portugal",
    "Research Centre for Physical Activity, Health and Leisure, Porto, Portugal"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Caroline Ferraz Simões"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Higor Barbosa Reck"
    },
    {
      "affs": [
        3
      ],
      "name": "João Carlos Locatelli"
    },
    {
      "affs": [
        0
      ],
      "name": "Gustavo Henrique de Oliveira"
    },
    {
      "affs": [
        0
      ],
      "name": "Victor Hugo de Souza Mendes"
    },
    {
      "affs": [
        0,
        4
      ],
      "name": "Rogério Toshiro Passos Okawa"
    },
    {
      "affs": [
        5,
        6
      ],
      "name": "Jamie O’Driscoll"
    },
    {
      "affs": [
        7,
        8
      ],
      "name": "Jorge Mota",
      "orcid": "0000-0001-7571-9181"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Wendell Arthur Lopes",
      "orcid": "0000-0001-7895-6799"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3mzx1m5jxgkfs.bib",
  "cited_by": 0,
  "doi": "10.1038/s41366-026-02158-4",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13722585/",
  "id": "3mzx1m5jxgkfs",
  "issns": [
    "0307-0565",
    "1476-5497"
  ],
  "landing_url": "https://doi.org/10.1038/s41366-026-02158-4",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Brief Communication"
    ],
    [
      "openalex",
      "2707|Cardiovascular and exercise physiology"
    ]
  ],
  "openalex": "W7167906203",
  "pdf_url": "https://www.nature.com/articles/s41366-026-02158-4.pdf",
  "pmcid": "PMC13722585",
  "pmid": "42432100",
  "published": "2026-07-10",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/3mzx1m5jxgkfs.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:21:22Z",
      "native_id": "PMC13722585",
      "source": "pmc",
      "url": "https://doi.org/10.1038/s41366-026-02158-4"
    }
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2707|Cardiovascular and exercise physiology",
      "subfield": "general"
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  ],
  "title": "High-intensity interval training improves myocardial work and cardiac function in women with obesity: a randomized controlled study",
  "title_text": "High-intensity interval training improves myocardial work and cardiac function in women with obesity: a randomized controlled study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T12:21:22Z",
  "url": "https://research.draconitic.com/paper/3mzx1m5jxgkfs",
  "venue": "International Journal of Obesity (2005)",
  "versions": []
}