{
  "abstract": "Background: Nirsevimab was introduced to prevent Respiratory Syncytial Virus (RSV) bronchiolitis in infants. Despite its proven effectiveness and similar guidelines across Europe, bronchiolitis reduction varied across Europe. This study explored whether nirsevimab coverage among targeted populations (born in- and out-of-season) was associated to this variability. Methods and findings: We used routinely collected data from 27 pediatric emergency departments across 12 European countries (01/2018–03/2024). All bronchiolitis cases aged <12 months were included. Regions were classified as intervention or control based on nirsevimab implementation. Coverage was obtained from official regional reports. We estimated changes in monthly case using controlled interrupted time-series models accounting for seasonality and temporal trends, by age-groups (0–3 and 3–12 months) and regions during the intervention period (10/2023–03/2024) and examined their correlation to coverage using Pearson’s test. Urinary tract infections served as a control outcome. Conclusions: This multinational interrupted time-series analysis identified coverage as a key factor associated to bronchiolitis reduction across age-groups and European regions. Implementation choices across Europe likely influenced coverage, highlighting that nirsevimab benefits depend not only on its intrinsic efficacy, but also on how effectively it is delivered. Why was this study done?: What did the researchers do and find?: What do these findings mean?: Using an interrupted time-series analysis, Léa Lenglart and colleagues explore whether heterogeneity in coverage in European countries of the RSV- targeting monoclonal antibody nirsevimab associates with differences in case counts of bronchiolitis in infants.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "Research Article",
  "arxiv": null,
  "author_total": 43,
  "authors": [
    {
      "name": "Léa Lenglart"
    },
    {
      "name": "Luigi Titomanlio"
    },
    {
      "name": "Ilaria Alberti"
    },
    {
      "name": "Laura Almeida"
    },
    {
      "name": "Camille Aupiais"
    },
    {
      "name": "Esra Akyüz Özkan"
    },
    {
      "name": "Michael Barrett"
    },
    {
      "name": "Romain Basmaci"
    },
    {
      "name": "Ahmet Birbilen"
    },
    {
      "name": "Dorine Borensztajn"
    },
    {
      "name": "Catarina Braz Schönenberger"
    },
    {
      "name": "Silvia Bressan"
    },
    {
      "name": "Danilo Buonsenso"
    },
    {
      "name": "Teresa Campos"
    },
    {
      "name": "Susana Castanhinha"
    },
    {
      "name": "Antonio Chiaretti"
    },
    {
      "name": "Gemma Claret"
    },
    {
      "name": "Francesca de Zan"
    },
    {
      "name": "Sheena Durnin"
    },
    {
      "name": "Laszlo Fodor"
    },
    {
      "name": "Borja Gomez"
    },
    {
      "name": "Susanne Greber-Platzer"
    },
    {
      "name": "Romain Guedj"
    },
    {
      "name": "Alexander Huege"
    },
    {
      "name": "Fiona Leonard"
    },
    {
      "name": "Ian Maconochie"
    },
    {
      "name": "Robin Marlow"
    },
    {
      "name": "Gregorio Milani"
    },
    {
      "name": "Miguel Angel Molina Gutierrez"
    },
    {
      "name": "Anna Maria Musolino"
    },
    {
      "name": "Rianne Oostenbrink"
    },
    {
      "name": "Zanda Pucuka"
    },
    {
      "name": "Simon Rivière"
    },
    {
      "name": "Damian Roland"
    },
    {
      "name": "Malin Ryd Rinder"
    },
    {
      "name": "Maria Chiara Supino"
    },
    {
      "name": "Ozlem Teksam"
    },
    {
      "name": "Victoria Trenchs"
    },
    {
      "name": "Zaba Valtuille"
    },
    {
      "name": "Bento Vanda"
    },
    {
      "name": "Sanne Vrijlandt"
    },
    {
      "name": "Naim Ouldali"
    },
    {
      "name": "Ruud G Nijman"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3n7vmg075ek96.bib",
  "cited_by": 0,
  "doi": "10.1371/journal.pmed.1005223",
  "fulltext_url": "https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1005223",
  "id": "3n7vmg075ek96",
  "issns": [
    "1549-1277",
    "1549-1676"
  ],
  "landing_url": "https://hal.science/hal-05791852v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
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    ],
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      "/Medicine and health sciences/Medical conditions/Respiratory disorders/Bronchiolitis"
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      "plos",
      "/People and places/Geographical locations/Europe/European Union/Spain"
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      "plos",
      "/People and places/Population groupings/Age groups/Children/Infants"
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      "plos",
      "/People and places/Population groupings/Families/Children/Infants"
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  "pdf_url": "https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1005223&type=printable",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-03",
  "publisher": "Public Library of Science",
  "ris": "https://research.draconitic.com/paper/3n7vmg075ek96.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:53Z",
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  "subjects": [
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  "title": "Association between nirsevimab coverage and pediatric emergency department visits for bronchiolitis in 12 European countries: An interrupted time-series analysis",
  "title_text": "Association between nirsevimab coverage and pediatric emergency department visits for bronchiolitis in 12 European countries: An interrupted time-series analysis",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:02Z",
  "url": "https://research.draconitic.com/paper/3n7vmg075ek96",
  "venue": "PLoS Medicine",
  "versions": []
}