{
  "abstract": "A new naturally occurring polyketide, pseurotin A ₃ -10,11-acetonide (1), along with two known analogs, pseurotin A (2) and pseurotin A ₃ (3), was isolated from the culture broth of Streptomyces sp. CSDX076. The structures of these compounds were determined by extensive 1D and 2D nuclear magnetic resonance (NMR), ultraviolet (UV), and high-resolution electrospray ionization mass spectrometry (HRESIMS) spectroscopic analyses. All isolated compounds (1-3) were evaluated for antimicrobial activity against a panel of seven pathogenic strains using disc diffusion and broth microdilution methods. Notably, compound 1 exhibited moderate activity against Brucella melitensis with a minimum inhibitory concentration (MIC) of 8.0 μg/mL, while compound 2 showed weak activity against Staphylococcus epidermidis (MIC = 128.0 μg/mL); compound 3 was inactive against all tested strains. This study reports, for the first time, the antibacterial effects of these compounds against the respective pathogens.",
  "abstract_shown": true,
  "affiliations": [
    "Guizhou Provincial Key Laboratory of Microbial Resources and Drug Development, Zunyi Medical University, Zunyi, Guizhou, China",
    "School of Stomatology, Zunyi Medical University, Zunyi, China",
    "Shool of Pharmacy, Zunyi Medical University, Zunyi, China",
    "Department of Chemistry, COMSATS University Islamabad, Abbottabad, Pakistan",
    "School of Basic Medical Sciences, Zunyi Medical University, Zunyi, China",
    "Yunnan Institute of Food Safety, Kunming University of Science and Technology, Zunyi, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Shengyan Qian"
    },
    {
      "affs": [
        2
      ],
      "name": "Hengxing Cai"
    },
    {
      "affs": [
        3
      ],
      "name": "Afsar Khan"
    },
    {
      "affs": [
        1
      ],
      "name": "Bin Chen"
    },
    {
      "affs": [
        4
      ],
      "name": "Li Tuo"
    },
    {
      "affs": [
        5
      ],
      "name": "Guiguang Cheng"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3nehj1sn99h3r.bib",
  "cited_by": 0,
  "doi": "10.7717/peerj.21830",
  "fulltext_url": "https://europepmc.org/articles/PMC13695420",
  "id": "3nehj1sn99h3r",
  "issns": [
    "2167-8359"
  ],
  "landing_url": "https://peerj.com/articles/21830",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "QH301-705.5"
    ],
    [
      "lcc",
      "R"
    ],
    [
      "openalex",
      "2736|Microbial Natural Products and Biosynthesis"
    ]
  ],
  "openalex": "W7223146553",
  "pdf_url": "https://peerj.com/articles/21830.pdf",
  "pmcid": "PMC13695420",
  "pmid": "42927119",
  "published": "2026-10-21",
  "publisher": "PeerJ",
  "ris": "https://research.draconitic.com/paper/3nehj1sn99h3r.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:47Z",
      "native_id": "10.7717/peerj.21830",
      "source": "crossref",
      "url": "https://peerj.com/articles/21830"
    },
    {
      "first_seen": "2026-10-30T12:21:18Z",
      "native_id": "MED:42927119",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42927119"
    },
    {
      "first_seen": "2026-10-30T13:44:15Z",
      "native_id": "5e65ba32667f4499a550787784a2c6bd",
      "source": "doaj",
      "url": "https://doi.org/10.7717/peerj.21830"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2736|Microbial Natural Products and Biosynthesis",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Polyketides from a soil -derived Streptomyces sp. CSDX076 and their antimicrobial activities",
  "title_text": "Polyketides from a soil -derived Streptomyces sp. CSDX076 and their antimicrobial activities",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:44:15Z",
  "url": "https://research.draconitic.com/paper/3nehj1sn99h3r",
  "venue": "PeerJ",
  "versions": []
}