{
  "abstract": "Post-myocardial infarction ventricular septal defect (pMI-VSD) remains a catastrophic mechanical complication of acute myocardial infarction despite advances in surgical management. We evaluated early and long-term outcomes after surgical repair of pMI-VSD at a tertiary referral center. We retrospectively reviewed 80 consecutive patients who underwent surgical repair of pMI-VSD between January 1995 and November 2025. Early outcomes, postoperative complications including residual shunting, and long-term all-cause mortality were analyzed. Long-term survival was estimated using the Kaplan-Meier method, and a parsimonious Cox proportional hazards model was used to identify factors associated with all-cause mortality. The mean age was 70.4±9.1 years, and 47.5% were male. The 30-day mortality rate was 7.5%. Residual shunts were detected in 35 patients (43.8%), of whom five (6.3% of the overall cohort) underwent reoperation. During a median observed follow-up of 58.5 months, 38 patients (47.5%) died. Estimated survival was 81.0% [95% confidence interval (CI): 72.8-90.1%] at 1 year, 70.5% (95% CI: 60.8-81.8%) at 5 years. In multivariable analysis, age and pre-existing chronic kidney disease (CKD) were associated with all-cause mortality. Survival differed between patients operated on in ≤2015 and >2015 (log-rank P=0.03), although this unadjusted comparison may reflect concurrent changes in patient characteristics and management. Favorable early and long-term outcomes were observed among selected patients who underwent surgical repair of pMI-VSD at an experienced center. Residual shunt status was not associated with a statistically detectable difference in long-term survival, although quantitative hemodynamic assessment was not uniformly available. Survival was better in the more recent era, although the contributions of changes in patient selection, surgical technique, and perioperative management cannot be distinguished in this observational cohort. However, this finding should be interpreted cautiously given the observational nature of the study.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Thoracic and Cardiovascular Surgery, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yoonseo Lee",
      "orcid": "0000-0003-4197-4728"
    },
    {
      "affs": [
        0
      ],
      "name": "Wook Sung Kim",
      "orcid": "0000-0001-7808-3385"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3p1x9kwa4970v.bib",
  "cited_by": 0,
  "doi": "10.21037/jtd-2026-2033",
  "fulltext_url": "https://europepmc.org/articles/PMC13740731",
  "id": "3p1x9kwa4970v",
  "issns": [
    "2072-1439",
    "2077-6624"
  ],
  "landing_url": "https://europepmc.org/article/MED/42996930",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2746|Cardiac Structural Anomalies and Repair"
    ]
  ],
  "openalex": "W7223345099",
  "pdf_url": "https://europepmc.org/articles/PMC13740731?pdf=render",
  "pmcid": "PMC13740731",
  "pmid": "42996930",
  "published": "2026-09-29",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/3p1x9kwa4970v.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T15:20:41Z",
      "native_id": "MED:42996930",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42996930"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Cardiac Structural Anomalies and Repair",
      "subfield": "surgery"
    }
  ],
  "title": "Surgical outcomes and long-term survival after repair of post-myocardial infarction ventricular septal defect: a 30-year single-center experience.",
  "title_text": "Surgical outcomes and long-term survival after repair of post-myocardial infarction ventricular septal defect: a 30-year single-center experience.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T15:20:41Z",
  "url": "https://research.draconitic.com/paper/3p1x9kwa4970v",
  "venue": "Journal of thoracic disease",
  "versions": []
}