{
  "abstract": "A 79-year-old female presented with progressive dyspnea. A bone marrow biopsy revealed hypoplastic marrow with abnormal lymphoid cells. A genetic analysis revealed a MYD88 p.V204F mutation, supporting the diagnosis of lymphoplasmacytic lymphoma/Waldenström's macroglobulinemia (LPL/WM). Additional evaluations established a concomitant diagnosis of aplastic anemia (AA). Treatment prioritized AA with cyclosporine and eltrombopag. Subsequently, the LPL/WM was treated with rituximab monotherapy. This sequential treatment resulted in a symptomatic improvement. Although AA is a diagnosis of exclusion, its coexistence with lymphoma is rare. This case highlights the diagnostic and therapeutic complexity of AA and LPL/WM overlap and suggests that prioritizing the treatment of AA may lead to better outcomes.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 15,
  "authors": [
    {
      "name": "Takehiro Okuda"
    },
    {
      "name": "Yuta Hanyu"
    },
    {
      "name": "Hana Mineshige"
    },
    {
      "name": "Yuta Inoue"
    },
    {
      "name": "Maki Sakurada"
    },
    {
      "name": "Masashi Matsui"
    },
    {
      "name": "Naomi Katsuki"
    },
    {
      "name": "Makoto Iwasaki"
    },
    {
      "name": "June Takeda"
    },
    {
      "name": "Junya Kanda"
    },
    {
      "name": "Yasuhito Nannya"
    },
    {
      "name": "Seishi Ogawa"
    },
    {
      "name": "Akifumi Takaori-Kondo"
    },
    {
      "name": "Yasuko Miyahara"
    },
    {
      "name": "Mitsuru Itoh"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3pf7m5mytc49q.bib",
  "cited_by": 0,
  "doi": "10.2169/internalmedicine.6790-25",
  "fulltext_url": "https://www.jstage.jst.go.jp/article/internalmedicine/65/20/65_6790-25/_article",
  "id": "3pf7m5mytc49q",
  "issns": [
    "1349-7235",
    "0918-2918"
  ],
  "landing_url": "https://www.jstage.jst.go.jp/article/internalmedicine/65/20/65_6790-25/_article",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "jstage-journal",
      "medicine/general"
    ],
    [
      "openalex",
      "2716|Chronic Lymphocytic Leukemia Research"
    ]
  ],
  "openalex": "W7134815685",
  "pdf_url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_6790-25/_pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-15",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/3pf7m5mytc49q.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:31Z",
      "native_id": "10.2169/internalmedicine.6790-25",
      "source": "jstage",
      "url": "https://www.jstage.jst.go.jp/article/internalmedicine/65/20/65_6790-25/_article"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2716|Chronic Lymphocytic Leukemia Research",
      "subfield": "human-genetics"
    }
  ],
  "title": "Severe Aplastic Anemia Concurrent with Lymphoplasmacytic Lymphoma/Waldenström's Macroglobulinemia",
  "title_text": "Severe Aplastic Anemia Concurrent with Lymphoplasmacytic Lymphoma/Waldenström's Macroglobulinemia",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:31Z",
  "url": "https://research.draconitic.com/paper/3pf7m5mytc49q",
  "venue": "Internal Medicine",
  "versions": []
}