{
  "abstract": "This strategic perspective proposes a governance-oriented conceptual model for sustainable, patient-partnered oncology research in Brazil, with regional relevance for Latin America and broader global implications. It argues that strengthening clinical research ecosystems, currently largely driven by the pharmaceutical industry, requires a refined balance of alignment among sponsors, investigators, institutions, regulators, and patients, recognizing that each operates under distinct strategic, operational, and ethical imperatives. The proposed framework emphasizes equity, meaningful clinical outcomes, and real-world relevance. It is presented as a governance heuristic inspired by strategic interdependence, recognizing that sustainable research ecosystems emerge from coordinated decisions among stakeholders with distinct incentives and responsibilities. A central architectural element is the positioning of patient organizations as institutional integrators of collaborative intelligence across stakeholders. This positioning supports Brazil as a strategic player in globally relevant oncology evidence, strengthening external validity and contributing to the evolution of international standards.",
  "abstract_shown": true,
  "affiliations": [
    "CURA Project Institute, São Paulo, Brazil.",
    "AW Scientific Engineering, Londrina, Brazil.",
    "Ethics Committee, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.",
    "Institute D'Or for Research and Education, Rede DOR, Rio de Janeiro, Brazil.",
    "Albert Einstein Israelite Hospital (HIAE), São Paulo, Brazil.",
    "Daiichi Sankyo, São Paulo, Brazil.",
    "Turi Saúde, São Paulo, Brazil.",
    "Division of Cancer Care and Epidemiology, Queen's University Cancer Research Institute, Kingston, Canada.",
    "Brazilian Hospital Services Network (EBSERH), Brasília, Brazil.",
    "Latin American Cooperative Oncology Group (LACOG), Porto Alegre, Brazil.",
    "Oncoclínicas Group, São Paulo, Brazil.",
    "Brazilian Society for Clinical Oncology (SBOC) (XXVI Congress Chair), Rio de Janeiro, Brazil.",
    "University Center of Volta Redonda (UNIFOA), Volta Redonda, Brazil."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 15,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Roberto J Arai"
    },
    {
      "affs": [
        0
      ],
      "name": "Fernanda Schwyter"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Luciana P Pereira"
    },
    {
      "affs": [
        3
      ],
      "name": "Clarissa Baldotto"
    },
    {
      "affs": [
        4
      ],
      "name": "Vanessa Teich"
    },
    {
      "affs": [
        5
      ],
      "name": "Gabriela Prior"
    },
    {
      "affs": [
        6
      ],
      "name": "Thiago Liguori"
    },
    {
      "affs": [
        7
      ],
      "name": "Christopher Booth"
    },
    {
      "affs": [
        8
      ],
      "name": "Felipe Roitberg"
    },
    {
      "affs": [
        0,
        4
      ],
      "name": "Max S Mano"
    },
    {
      "affs": [
        9
      ],
      "name": "Carlos E Barrios"
    },
    {
      "affs": [
        0,
        10,
        11
      ],
      "name": "William N William"
    },
    {
      "affs": [
        12
      ],
      "name": "Bernardo Caetano Novaes"
    },
    {
      "affs": [
        12
      ],
      "name": "Nataline Freitas de Azevedo Santos"
    },
    {
      "affs": [
        0,
        12
      ],
      "name": "Heloisa M Resende"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3pz30kdj45jps.bib",
  "cited_by": 0,
  "doi": "10.1016/j.lana.2026.101679",
  "fulltext_url": "https://europepmc.org/articles/PMC13695104",
  "id": "3pz30kdj45jps",
  "issns": [
    "2667-193X"
  ],
  "landing_url": "https://europepmc.org/article/MED/42926955",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2739|Health and Medical Research Impacts"
    ]
  ],
  "openalex": "W7222914971",
  "pdf_url": "https://europepmc.org/articles/PMC13695104?pdf=render",
  "pmcid": "PMC13695104",
  "pmid": "42926955",
  "published": "2026-10-19",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/3pz30kdj45jps.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:18Z",
      "native_id": "MED:42926955",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42926955"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2739|Health and Medical Research Impacts",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Collaborative intelligence for sustainable and patient-partnered clinical research.",
  "title_text": "Collaborative intelligence for sustainable and patient-partnered clinical research.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:18Z",
  "url": "https://research.draconitic.com/paper/3pz30kdj45jps",
  "venue": "Lancet regional health. Americas",
  "versions": []
}