{
  "abstract": "Objective: Poor inhibitory control may decrease weight loss maintenance. The neurobiological mechanisms are poorly understood. We investigated whether glutamate modulation in the anterior mid-cingulate cortex (aMCC) during response inhibition is impacted by food-cues and associated with self-reported behaviors and weight loss maintenance. Methods: 27 adults with overweight/obesity were recruited from a clinical weight management program. 1H fMRS (midline aMCC) was acquired during a visual-guided response inhibition task engaging two responding modes [non-selective (100% responses) or selective (withholding a response on 20% of trials)] applied with neutral (squares) or food/non-food cues. The impact of stimulus type on the aMCC glutamate modulation for each responding mode was assessed using a repeated measures GEE approach. Correlations were conducted between glutamate modulation, Three-Factor Eating Questionnaire scores, and long-term weight change. Results: The stimulus effect was significant during selective responding, driven by lower aMCC glutamate modulation during food/non-food cues. This glutamate modulation (selective; food/non-food) association with weight loss maintenance was a close trend (R2=0.15, p=0.054). The association with the TFEQ Cognitive Restraint was significant (R2=0.20, p=0.047). Conclusions: These results demonstrate an impact of food/non-food cues during response inhibition on the neurobiology and associations with long-term weight loss maintenance and scores related to eating behaviors.",
  "abstract_shown": true,
  "affiliations": [
    "Virginia Tech"
  ],
  "article_type": "PUBLISHAHEADOFPRINT",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "J. M. Eichstaedt"
    },
    {
      "name": "R. Sochocki"
    },
    {
      "name": "D. Khatib"
    },
    {
      "name": "N. Miller"
    },
    {
      "name": "V. A. Diwadkar"
    },
    {
      "name": "P. Burghardt"
    },
    {
      "name": "A. Rothberg"
    },
    {
      "name": "J. A. Stanley"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3pz4z55fbq95e.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.27.26366634",
  "fulltext_url": "https://www.medrxiv.org/content/10.64898/2026.10.27.26366634v1.full",
  "id": "3pz4z55fbq95e",
  "issns": [],
  "landing_url": "https://www.medrxiv.org/content/10.64898/2026.10.27.26366634v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "medrxiv",
      "psychiatry and clinical psychology"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://www.medrxiv.org/content/10.64898/2026.10.27.26366634v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-27",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/3pz4z55fbq95e.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:03Z",
      "native_id": "10.64898/2026.10.27.26366634",
      "source": "medrxiv",
      "url": "https://www.medrxiv.org/content/10.64898/2026.10.27.26366634v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "medrxiv:psychiatry and clinical psychology",
      "subfield": "psychiatry"
    }
  ],
  "title": "Effect of food-cues on aMCC glutamate modulation during inhibitory control post weight loss intervention: a 1H fMRS study",
  "title_text": "Effect of food-cues on aMCC glutamate modulation during inhibitory control post weight loss intervention: a 1H fMRS study",
  "type": "preprint",
  "updated_at": "2026-10-31T00:20:35Z",
  "url": "https://research.draconitic.com/paper/3pz4z55fbq95e",
  "venue": "medRxiv",
  "versions": []
}