{
  "abstract": "Cachexia or body wasting is a significant contributing factor to the morbidity and mortality of pancreatic cancer. Despite an unmet need, its metabolic underpinnings remain poorly understood. Here, we characterize a mouse model that recaptures the longitudinal progression of human cachexia during pancreatic cancer development. We profile the metabolomes of pre-, early- and late-stage cancer-associated cachexia in male and female pancreas, its interstitial fluid (IF), plasma, liver, adipose tissue and skeletal muscle. We find that each tissue has a unique metabolome and trajectory across stages and reveal a marked lipid enrichment in the tumor IF. Using mathematical modeling, we identify metabolites participating in cross-tissue networks and in vivo validate a lactate-glucose conversion. We find systemic metabolic changes prior to weight loss and use feature selection algorithms to identify early detection markers. Our study provides a resource for system-wide metabolic evolution of pancreatic cancer and associated cachexia, highlighting the potential for timely diagnostics and interventions.",
  "abstract_shown": true,
  "affiliations": [
    "Division of Endocrinology, Boston Children's Hospital, Boston, MA, USA.",
    "Department of Pediatrics, Harvard Medical School, Boston, MA, USA.",
    "Metabolomics Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.",
    "Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.",
    "Department of Pathology, Harvard Medical School, Boston, MA, USA.",
    "Computational and Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.",
    "Division of Endocrinology, Boston Children's Hospital, Boston, MA, USA. mathur.30@osu.edu.",
    "Department of Pediatrics, Harvard Medical School, Boston, MA, USA. mathur.30@osu.edu.",
    "Computational and Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA. mathur.30@osu.edu.",
    "The Ohio State University Comprehensive Cancer Center & Department of Molecular Medicine and Therapeutics, The Ohio State University College of Medicine, Columbus, OH, USA. mathur.30@osu.edu.",
    "Division of Endocrinology, Boston Children's Hospital, Boston, MA, USA. nada.kalaany@childrens.harvard.edu.",
    "Department of Pediatrics, Harvard Medical School, Boston, MA, USA. nada.kalaany@childrens.harvard.edu.",
    "Broad Institute of MIT and Harvard, Cambridge, MA, USA. nada.kalaany@childrens.harvard.edu."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Blanca Majem"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Min-Sik Lee",
      "orcid": "0000-0002-0563-8113"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Kyung Cheul Shin"
    },
    {
      "affs": [
        0
      ],
      "name": "Insia Naqvi"
    },
    {
      "affs": [
        2
      ],
      "name": "Courtney Dennis"
    },
    {
      "affs": [
        2
      ],
      "name": "Lucas Dailey",
      "orcid": "0000-0003-3204-9565"
    },
    {
      "affs": [
        2
      ],
      "name": "Sarah Jeanfavre"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Mari Mino-Kenudson"
    },
    {
      "affs": [
        5
      ],
      "name": "Joao B Xavier",
      "orcid": "0000-0003-3592-1689"
    },
    {
      "affs": [
        2
      ],
      "name": "Clary B Clish",
      "orcid": "0000-0001-8259-9245"
    },
    {
      "affs": [
        6,
        7,
        8,
        9
      ],
      "name": "Deepti Mathur",
      "orcid": "0000-0002-2193-9127"
    },
    {
      "affs": [
        10,
        11,
        12
      ],
      "name": "Nada Y Kalaany",
      "orcid": "0000-0001-7489-1035"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3q0nxbwxcsfr6.bib",
  "cited_by": 0,
  "doi": "10.1038/s41467-026-77745-0",
  "fulltext_url": "https://europepmc.org/articles/PMC13680358",
  "id": "3q0nxbwxcsfr6",
  "issns": [
    "2041-1723"
  ],
  "landing_url": "https://europepmc.org/article/MED/42897170",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2737|Nutrition and Health in Aging"
    ]
  ],
  "openalex": "W7213561185",
  "pdf_url": "https://europepmc.org/articles/PMC13680358?pdf=render",
  "pmcid": "PMC13680358",
  "pmid": "42897170",
  "published": "2026-09-18",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/3q0nxbwxcsfr6.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:41Z",
      "native_id": "MED:42897170",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42897170"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2737|Nutrition and Health in Aging",
      "subfield": "physiology"
    }
  ],
  "title": "Spatiotemporal metabolic networks in a preclinical model of pancreatic cancer and associated cachexia.",
  "title_text": "Spatiotemporal metabolic networks in a preclinical model of pancreatic cancer and associated cachexia.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:41Z",
  "url": "https://research.draconitic.com/paper/3q0nxbwxcsfr6",
  "venue": "Nature communications",
  "versions": []
}