{
  "abstract": "Heart failure is characterized by extracellular matrix remodeling and collagen deposition that impair myocardial function. Second harmonic generation (SHG) microscopy provides label-free visualization of fibrillar collagen and myosin but lacks standardized, interpretable, and quantitative frameworks with clinical-level performance. We present a feature extraction pipeline integrating 87 biologically interpretable SHG-derived metrics for automated classification of nonischemic heart failure in murine specimen. The framework distinguished normal, heart failure, and natural recovery states with area-under-the-curve values of 0.84-0.99, outperforming established open-source SHG feature extraction tools. These findings support interpretable, SHG-based quantification of cardiac remodeling and establish a methodology for future multimodal biophotonics applications.",
  "abstract_shown": true,
  "affiliations": [
    "Houston Methodist Research Institute"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "name": "R. Master"
    },
    {
      "name": "W. Poon"
    },
    {
      "name": "R. Uzma"
    },
    {
      "name": "S. Bannikov"
    },
    {
      "name": "M. K. Krishnamoorthi"
    },
    {
      "name": "A. Veeraraghavan"
    },
    {
      "name": "H. ZHAO"
    },
    {
      "name": "A. Bhimaraj"
    },
    {
      "affs": [
        0
      ],
      "name": "R. Raghunathan"
    },
    {
      "name": "S. T. Wong"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3q2wkgqqkh7fz.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.21.760498",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.10.21.760498v1.full",
  "id": "3q2wkgqqkh7fz",
  "issns": [
    "2692-8205"
  ],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.10.21.760498v1",
  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "bioengineering"
    ],
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "2705|Cardiac Fibrosis and Remodeling"
    ]
  ],
  "openalex": "W7223303109",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.10.21.760498v1.full.pdf",
  "pmcid": "PMC13738757",
  "pmid": "42996145",
  "published": "2026-10-21",
  "publisher": "Cold Spring Harbor Laboratory Preprints",
  "ris": "https://research.draconitic.com/paper/3q2wkgqqkh7fz.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:29:18Z",
      "native_id": "10.64898/2026.10.21.760498",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.10.21.760498v1"
    },
    {
      "first_seen": "2026-11-09T12:23:41Z",
      "native_id": "PMC13738757",
      "source": "pmc",
      "url": "https://doi.org/10.64898/2026.10.21.760498"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:bioengineering",
      "subfield": "systems-synthetic"
    }
  ],
  "title": "Interpretable computational SHG microscopy enables quantitative tissue phenotyping of cardiac remodeling in nonischemic heart failure",
  "title_text": "Interpretable computational SHG microscopy enables quantitative tissue phenotyping of cardiac remodeling in nonischemic heart failure",
  "type": "preprint",
  "updated_at": "2026-11-09T12:23:41Z",
  "url": "https://research.draconitic.com/paper/3q2wkgqqkh7fz",
  "venue": "bioRxiv",
  "versions": []
}