{
  "abstract": "Background\n\nBreast cancer is the most common invasive malignancy in women. Ultrasound viscoelastography may improve non-invasive diagnosis, but the clinical relevance of peritumoral viscoelastic parameters (VPs) and their correlation with Ki-67 remain unclear. This study explores these associations.Methods\n\nA prospective study enrolled 256 breast masses (156 malignant, 100 benign). Patients underwent conventional ultrasound and viscoelastography. VPs were acquired within masses (A), peritumoral shells (Shell1: 1 mm, Shell2: 2 mm, Shell3: 3 mm), and combined regions (A' = A + Shell). Quantitative metrics included elasticity (V/1 E, V/0 E), dispersion coefficient (V/1 D), viscosity coefficient (V/0 V), and their maximum (Max), minimum (Min), mean(Mean), and standard deviation (SD) values. Diagnostic performance was evaluated by analyzing the receiver operating characteristic (ROC) curve and calculating the area under the curve (AUC), followed by logistic regression. VPs were compared between high/low Ki-67 groups.Results\n\nThe AUCs of peritumoral VPs exceeded those from masses. V/1 D showed higher AUC than V/0 V and elasticity values, with Shell3 V/1 D SD having the highest AUC (0.840). The diagnostic efficacy of the peritumoral viscoelastic model surpassed that of the single elasticity parameter model, with 89.1% sensitivity, 73% specificity, 82.8% accuracy. Key variables included Shell3 V/1 D and Shell3 V/0 E. Shell1 V/0 V Max was significantly higher in high versus low Ki-67 expression groups (p < 0.05).Conclusion\n\nThe viscoelastic model improves diagnostic accuracy by quantifying peritumoral biomechanics, and certain VPs may predict Ki-67 expression. Peritumoral VPs show potential as novel non-invasive imaging biomarkers for early breast cancer evaluation.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Ultrasound The First Affiliated Hospital of Jinan University Guangzhou China.",
    "Department of Ultrasound The People's Hospital of Guangxi Zhuang Autonomous Region, Guangxi Academy of Medical Sciences Nanning China.",
    "Department of Radiology The People's Hospital of Guangxi Zhuang Autonomous Region, Guangxi Academy of Medical Sciences Nanning China.",
    "Department of Breast Surgery The People's Hospital of Guangxi Zhuang Autonomous Region, Guangxi Academy of Medical Sciences Nanning China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Xiaoli Huang",
      "orcid": "0000-0002-3195-8508"
    },
    {
      "affs": [
        1
      ],
      "name": "Bing Zhang"
    },
    {
      "affs": [
        1
      ],
      "name": "Fei Chen"
    },
    {
      "affs": [
        1
      ],
      "name": "Chunxiang Wei",
      "orcid": "0009-0001-7089-7293"
    },
    {
      "affs": [
        1
      ],
      "name": "Bei Lan"
    },
    {
      "affs": [
        1
      ],
      "name": "Huihui Yang"
    },
    {
      "affs": [
        2
      ],
      "name": "Demao Deng",
      "orcid": "0000-0002-7565-2607"
    },
    {
      "affs": [
        3
      ],
      "name": "Quanqing Zou",
      "orcid": "0000-0002-6195-2924"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3q9wxwtvggbdb.bib",
  "cited_by": 0,
  "doi": "10.1002/hsr2.73394",
  "fulltext_url": "https://europepmc.org/articles/PMC13678117",
  "id": "3q9wxwtvggbdb",
  "issns": [
    "2398-8835"
  ],
  "landing_url": "https://europepmc.org/article/MED/42898743",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2741|Ultrasound Imaging and Elastography"
    ]
  ],
  "openalex": "W7222920960",
  "pdf_url": "https://europepmc.org/articles/PMC13678117?pdf=render",
  "pmcid": "PMC13678117",
  "pmid": "42898743",
  "published": "2026-10-18",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/3q9wxwtvggbdb.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:33Z",
      "native_id": "MED:42898743",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42898743"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2741|Ultrasound Imaging and Elastography",
      "subfield": "imaging"
    }
  ],
  "title": "Advancing Early Breast Cancer Diagnosis and Ki-67 Expression Prediction With Ultrasound Viscoelastography: Based on Peritumoral Assessment.",
  "title_text": "Advancing Early Breast Cancer Diagnosis and Ki-67 Expression Prediction With Ultrasound Viscoelastography: Based on Peritumoral Assessment.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:33Z",
  "url": "https://research.draconitic.com/paper/3q9wxwtvggbdb",
  "venue": "Health science reports",
  "versions": []
}