{
  "abstract": "The shortage of transplantable organs remains one of the most significant unmet challenges in modern medicine. Despite advances in donor management, organ preservation, surgical techniques, and immunosuppression, organ demand continues to exceed supply worldwide. Xenotransplantation using genetically engineered porcine organs has emerged as a promising strategy to address this gap. Recent clinical pig-to-human heart and kidney transplantations have demonstrated the feasibility of clinical xenotransplantation and shifted attention from immunological barriers toward practical implementation. This review examines the logistical requirements for clinical xenotransplantation, with particular emphasis on donor herd management, biosafety, organ preservation technologies, and future distribution networks. The integration of donor production with advanced machine perfusion technologies may ultimately transform transplantation medicine from a donor-dependent emergency service into a predictable and scalable therapeutic platform.",
  "abstract_shown": true,
  "affiliations": [
    "Walter Brendel Center of Experimental Medicine, Institute of Surgical Research, University Hospital, LMU Munich , ,",
    "Institute of Virology, Free University Berlin , ,",
    "Paul-Ehrlich-Institut, Federal Institute for Vaccines and Biomedicines , ,",
    "Department of General, Visceral and Transplant Surgery, Hannover Medical School , ,",
    "German Organ Transplantation Foundation , ,"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Konrad Fischer"
    },
    {
      "affs": [
        1
      ],
      "name": "Joachim Denner"
    },
    {
      "affs": [
        2
      ],
      "name": "Ralf Reinhard Tönjes"
    },
    {
      "affs": [
        3
      ],
      "name": "Philipp Felgendreff"
    },
    {
      "affs": [
        4
      ],
      "name": "Axel Rahmel"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3qft235fgsa10.bib",
  "cited_by": 0,
  "doi": "10.3389/ti.2026.17326",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13716711/?tool=EBI",
  "id": "3qft235fgsa10",
  "issns": [
    "0934-0874",
    "1432-2277"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13716711",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review"
    ],
    [
      "openalex",
      "2746|Xenotransplantation and immune response"
    ]
  ],
  "openalex": "W7222181175",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13716711/pdf/?tool=EBI",
  "pmcid": "PMC13716711",
  "pmid": "42959085",
  "published": "2026-10-15",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/3qft235fgsa10.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:37Z",
      "native_id": "PMC:PMC13716711",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13716711"
    },
    {
      "first_seen": "2026-11-01T00:20:52Z",
      "native_id": "MED:42959085",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42959085"
    },
    {
      "first_seen": "2026-11-01T12:23:56Z",
      "native_id": "PMC13716711",
      "source": "pmc",
      "url": "https://doi.org/10.3389/ti.2026.17326"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Xenotransplantation and immune response",
      "subfield": "surgery"
    }
  ],
  "title": "Logistics of clinical xenotransplantation: from donor pig production to global organ distribution",
  "title_text": "Logistics of clinical xenotransplantation: from donor pig production to global organ distribution",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:21:09Z",
  "url": "https://research.draconitic.com/paper/3qft235fgsa10",
  "venue": "Transplant international : official journal of the European Society for Organ Transplantation",
  "versions": []
}