{
  "abstract": "Introduction: Acellular scleral allograft-reinforced cyclodialysis is a bio-interventional surgery (BIOS) to lower intraocular pressure (IOP). We report 2-year efficacy and safety outcomes when the procedure is performed in combination with phacoemulsification and as a standalone procedure in eyes with open-angle glaucoma. Methods: Analysis of the multicenter CREST real-world evidence study of eyes undergoing allograft-reinforced cyclodialysis with AlloFlo Uveo (Iantrek, Inc., White Plains, NY; NCT05506423). Eyes attending the Month-24 visit were analyzed: 176 eyes undergoing phaco-combined surgery (Cohort 1) and 32 standalone eyes (Cohort 2). Values recorded after secondary procedures censored. Cohort 1 only was stratified by low, moderate, or high baseline IOP ([≤] 15, 16-20, [≥] 21 mmHg). Results: A total of 176 eyes in Cohort 1 and 32 in Cohort 2 were analyzed. In Cohort 1, IOP decreased 3.1 mmHg at Month 24 from a baseline of 18.0 (-12.5%; p < 0.001), and medications decreased 0.5 from 1.5 (p < 0.001); medication-free eyes rose from 22.9% to 46.4% (p < 0.001). IOP changes in the low, moderate, and high baseline tiers were +0.9 (+7.8%), -3.0 (-16.3%), and -9.2 (-36.1%) mmHg; medication changes were -0.8, -0.6, and +0.1. In Cohort 2, IOP decreased 6.4 mmHg from 20.0 (-27.1%; p < 0.001), and medications decreased 1.2 from 2.8 (p = 0.004); medication-free eyes rose from 4.3% to 30.4% (p = 0.031). Secondary IOP-lowering procedures were performed in 5.1% of Cohort 1 eyes and 28.1% of Cohort 2. Kaplan-Meier freedom from reoperation was 98.9% and 84.4%. No eye developed clinically significant hypotony or choroidal effusion, and there were no allograft-related vision-threatening adverse events. Conclusion: Allograft-reinforced cyclodialysis effectively lowered IOP and medication use through 24 months.",
  "abstract_shown": true,
  "affiliations": [
    "New York Eye and Ear of Mount Sinai, New York, NY, USA"
  ],
  "article_type": "PUBLISHAHEADOFPRINT",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "name": "R. N. Weinreb"
    },
    {
      "name": "L. Provencher"
    },
    {
      "name": "A. S. Huang"
    },
    {
      "name": "A. Yadgarov"
    },
    {
      "name": "M. Rouse"
    },
    {
      "name": "B. Francis"
    },
    {
      "affs": [
        0
      ],
      "name": "T. Ianchulev"
    },
    {
      "name": "R. Chang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3qhe1r2rv1w09.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.11.02.26367111",
  "fulltext_url": "https://www.medrxiv.org/content/10.64898/2026.11.02.26367111v1.full",
  "id": "3qhe1r2rv1w09",
  "issns": [],
  "landing_url": "https://www.medrxiv.org/content/10.64898/2026.11.02.26367111v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "medrxiv",
      "ophthalmology"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://www.medrxiv.org/content/10.64898/2026.11.02.26367111v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-02",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/3qhe1r2rv1w09.ris",
  "sources": [
    {
      "first_seen": "2026-11-05T12:20:16Z",
      "native_id": "10.64898/2026.11.02.26367111",
      "source": "medrxiv",
      "url": "https://www.medrxiv.org/content/10.64898/2026.11.02.26367111v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "medrxiv:ophthalmology",
      "subfield": "general"
    }
  ],
  "title": "Scleral Allograft-Reinforced Cyclodialysis Combined with Phacoemulsification or Performed as a Standalone Procedure: 24-Month Outcomes from the Multicenter CREST Study",
  "title_text": "Scleral Allograft-Reinforced Cyclodialysis Combined with Phacoemulsification or Performed as a Standalone Procedure: 24-Month Outcomes from the Multicenter CREST Study",
  "type": "preprint",
  "updated_at": "2026-11-07T00:20:51Z",
  "url": "https://research.draconitic.com/paper/3qhe1r2rv1w09",
  "venue": "medRxiv",
  "versions": []
}