{
  "abstract": "ObjectiveTo explore the effects of chronic ankle instability (CAI) on ipsilateral knee cartilage degeneration and the coupling relationship between the two joints through mouse model.MethodsThirty C57BL/6J mice were divided into the Sham group, the CAI group, and the destabilization of medial meniscus (DMM) group. They were respectively subjected to sham surgery, anterior talofibular ligament and calcaneofibular ligament transection, and medial meniscus resection. The degeneration of knee cartilage was evaluated through kinematic experiments, imaging examinations and histopathological analysis within 12 weeks post-operation.ResultsThe kinematic experiments exhibited significantly increased passing time and number of slips for CAI group compared to DMM group and Sham group during crossing the balance beam; the step length and step width of CAI group were also larger. Imaging examination revealed obvious osteochondral defects and osteosclerosis of the femoral condyles both in CAI group and DMM group at 12 weeks post-operation. However, the DMM group was more severely affected than CAI group, as its bone mineral density and bone volume fraction were both higher than CAI group. Histopathological analysis exhibited thinner cartilage layer, less chondrocytes and more disordered collagen fibers in DMM group than CAI group at 6 and 12 weeks post-operation. The modified Mankin score and OARSI score of DMM group were also significantly higher than CAI group, while both groups were higher than Sham group.ConclusionsCAI can cause cartilage degeneration of ipsilateral knee joint in mouse model, there is a coupling relationship between ankle joint and knee joint.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou, China",
    "Department of Orthopedics, Changshu Hospital Affiliated to Soochow University, Changshu No.1 People's Hospital, Changshu, Jiangsu, China",
    "Department of Nephrology, Affiliated Changshu Hospital of Nantong University, Changshu No.2 People's Hospital, Changshu, Jiangsu, China",
    "School of Physical Education and Sports, Soochow University, Suzhou, Jiangsu, China"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 9,
  "authors": [
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      "name": "Zhi Chen"
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    {
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        1
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      "name": "Zhi Chen"
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    {
      "affs": [
        2
      ],
      "name": "Fanglu Xu"
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    {
      "affs": [
        1
      ],
      "name": "Bingqian Chen"
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    {
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        1
      ],
      "name": "Zhengfei Wang"
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    {
      "affs": [
        1
      ],
      "name": "Xiaohong Qu"
    },
    {
      "affs": [
        1
      ],
      "name": "Yao Fu"
    },
    {
      "affs": [
        3
      ],
      "name": "Jia Yu"
    },
    {
      "affs": [
        0
      ],
      "name": "Hongtao Zhang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3qkvx03kf933g.bib",
  "cited_by": 0,
  "doi": "10.3389/fmedt.2026.1854284",
  "fulltext_url": "https://www.frontiersin.org/articles/10.3389/fmedt.2026.1854284/full",
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  "landing_url": "https://doi.org/10.3389/fmedt.2026.1854284",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
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  "pdf_url": "https://www.frontiersin.org/journals/medical-technology/articles/10.3389/fmedt.2026.1854284/pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-26",
  "publisher": "Frontiers Media S.A.",
  "ris": "https://research.draconitic.com/paper/3qkvx03kf933g.ris",
  "sources": [
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      "first_seen": "2026-10-30T13:47:29Z",
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  "title": "Effects of chronic ankle instability on ipsilateral knee cartilage degeneration in mouse model",
  "title_text": "Effects of chronic ankle instability on ipsilateral knee cartilage degeneration in mouse model",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:47:29Z",
  "url": "https://research.draconitic.com/paper/3qkvx03kf933g",
  "venue": "Frontiers in Medical Technology",
  "versions": []
}