{
  "abstract": "Plasma bioassays provide functional measures of environmental mixtures whose relationship with clinical biochemistry warrants investigation. We examined dioxin-responsive chemically activated luciferase gene expression (DR-CALUX) bioactivity in the 600-participant intensive-biomonitoring subgroup of SPES in Campania, Italy. Quantifiable bioactivity was available for 594 participants, of whom 592 entered the principal analyses. Mixed models assessed the lipid-standardised DR-CALUX index in relation to two primary thyroid outcomes, nine secondary outcomes, and an exploratory panel of 54 clinical markers. Per index doubling, thyroid-stimulating hormone differed by −7.23% (95% CI −14.96 to 1.21; Holm-adjusted p = 0.182), and free thyroxine differed by −0.0047 ng/dL (−0.0233 to 0.0139; adjusted p = 0.621). Alanine and aspartate aminotransferase activities were lower by 9.33% (−14.22 to −4.17) and 8.01% (−12.31 to −3.50), respectively; both met the hepatic-family Benjamini–Hochberg criterion. Inverse estimates persisted with separate lipid adjustment and attenuated but remained inverse after restriction using common laboratory-report upper thresholds for both aminotransferases. All 54 global Benjamini–Yekutieli-adjusted p values exceeded 0.05; only the aminotransferases met the Benjamini–Hochberg comparison. These secondary aminotransferase associations merit further investigation of their biological basis and clinical significance. The primary thyroid findings remain inconclusive.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Public Health, University of Naples “Federico II”, Via Sergio Pansini 5, 80131 Naples, Italy",
    "Department of Human Sciences and Quality of Life Promotion, San Raffaele University, 00166 Rome, Italy"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Pellegrino Cerino",
      "orcid": "0009-0009-7944-239X"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Elvira De Rosa"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Maria Triassi"
    },
    {
      "affs": [
        0
      ],
      "name": "Paolo Montuori"
    },
    {
      "affs": [
        0
      ],
      "name": "Carlo Buonerba"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3qrqzm32cjb5g.bib",
  "cited_by": 0,
  "doi": "10.3390/ijms272110017",
  "fulltext_url": null,
  "id": "3qrqzm32cjb5g",
  "issns": [
    "1422-0067"
  ],
  "landing_url": "https://www.mdpi.com/1422-0067/27/21/10017",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-08",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/3qrqzm32cjb5g.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:22:39Z",
      "native_id": "10.3390/ijms272110017",
      "source": "crossref",
      "url": "https://www.mdpi.com/1422-0067/27/21/10017"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "issn:1422-0067",
      "subfield": "general"
    }
  ],
  "title": "Plasma DR-CALUX Bioactivity and Concurrent Clinical Biochemistry: A Secondary Cross-Sectional Analysis of SPES",
  "title_text": "Plasma DR-CALUX Bioactivity and Concurrent Clinical Biochemistry: A Secondary Cross-Sectional Analysis of SPES",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:22:39Z",
  "url": "https://research.draconitic.com/paper/3qrqzm32cjb5g",
  "venue": "International Journal of Molecular Sciences",
  "versions": []
}