{
  "abstract": "Context:: Mean arterial pressure targets during cardiopulmonary bypass remain debated; vasopressor-driven pressure augmentation may not improve oxygen delivery.\n\nAims:: The aim of the paper is to describe clinical outcomes and physiologic markers during normothermic cardiopulmonary bypass managed with indexed flow, cerebral oximetry, calculated indexed oxygen delivery (DO2i), and vasopressor-sparing pressure management.\n\nSettings and Design:: Single-center retrospective descriptive cohort study at a cardiac surgery center.\n\nMaterial and Methods:: Consecutive adults undergoing elective or urgent cardiac surgery with normothermic cardiopulmonary bypass from June 2023 to December 2025 were included if complete anesthesia–perfusion, regional cerebral oxygen saturation (rSO2), circuit-derived venous oxygen saturation (SvO2), DO2i, and early outcome data were available. Circulatory arrest was excluded. Indexed pump flow was 2.2–2.4 L/min/m². Mean arterial pressure was interpreted with indexed flow, rSO2, SvO2, DO2i, hemoglobin, acid–base status, venous return, and surgical context. Baseline rSO2 was recorded before ventilation on room air; maximal relative decrease during bypass was recorded.\n\nStatistical Analysis Used:: Descriptive statistics and Wilson 95% confidence intervals were used. No comparative testing or causal modeling was performed.\n\nResults:: Two hundred patients were analyzed. Operating-room extubation was achieved in 172 patients (86.0%). Stroke occurred in six (3.0%), acute kidney injury in two (1.0%), and venoarterial extracorporeal membrane oxygenation was required in six (3.0%). Baseline right and left rSO2 were 57.5 ± 11.2% and 58.5 ± 11.3%; maximal relative rSO2 decrease was 28.5 ± 3.4%; circuit-derived SvO2 was 67.4 ± 5.9%; and calculated DO2i was 611 ± 74 mL/min/m².\n\nConclusions:: This flow-oriented, cerebral oximetry-guided, oxygen-delivery-aware strategy was accompanied by favorable early recovery. Because the study was retrospective and noncomparative, the findings are hypothesis-generating.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Anesthesiology and Intensive, Botkin Hospital, Moscow, Russia",
    "Department of Cardiac Surgery, Botkin Hospital, Moscow, Russia"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Nikita Chibisov"
    },
    {
      "affs": [
        0
      ],
      "name": "Andrey Kornienko"
    },
    {
      "affs": [
        0
      ],
      "name": "Anatoly Malyshev"
    },
    {
      "affs": [
        0
      ],
      "name": "Evgeny Rodionov"
    },
    {
      "affs": [
        1
      ],
      "name": "Igor Glushenko"
    },
    {
      "affs": [
        0
      ],
      "name": "Mikhail Shtrymov"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3r2e9kr86em7z.bib",
  "cited_by": 0,
  "doi": "10.4103/aca.aca_170_26",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13743094/",
  "id": "3r2e9kr86em7z",
  "issns": [
    "0971-9784",
    "0974-5181"
  ],
  "landing_url": "https://doi.org/10.4103/aca.aca_170_26",
  "language": "en",
  "licence": "CC-BY-NC-SA-4.0",
  "licence_label": "CC BY-NC-SA 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-sa/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "2746|Cardiac and Coronary Surgery Techniques"
    ]
  ],
  "openalex": "W7221547942",
  "pdf_url": null,
  "pmcid": "PMC13743094",
  "pmid": "42862675",
  "published": "2026-10-12",
  "publisher": "Wolters Kluwer -- Medknow Publications",
  "ris": "https://research.draconitic.com/paper/3r2e9kr86em7z.ris",
  "sources": [
    {
      "first_seen": "2026-11-10T12:23:49Z",
      "native_id": "PMC13743094",
      "source": "pmc",
      "url": "https://doi.org/10.4103/aca.aca_170_26"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Cardiac and Coronary Surgery Techniques",
      "subfield": "surgery"
    }
  ],
  "title": "Cerebral Oxygenation-Guided Indexed-Flow Normothermic Cardiopulmonary Bypass with Vasopressor-Sparing Pressure Management: A Retrospective Descriptive Cohort Study",
  "title_text": "Cerebral Oxygenation-Guided Indexed-Flow Normothermic Cardiopulmonary Bypass with Vasopressor-Sparing Pressure Management: A Retrospective Descriptive Cohort Study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-10T12:23:49Z",
  "url": "https://research.draconitic.com/paper/3r2e9kr86em7z",
  "venue": "Annals of Cardiac Anaesthesia",
  "versions": []
}