{
  "abstract": "Recent taxonomic revisions based on molecular phylogenetics transferred species from Gochnatia to Moquiniastrum, which now includes 22 species, 20 of which occur in Brazil with an extra-Amazonian distribution. Here, we report a phytochemical study of Moquiniastrum sordidum (Less.) G. Sancho. Chromatographic separation afforded eight compounds, including two new metabolites: a sesquiterpene (5) and a phenolic glycoside (8). The known compounds were identified as simiarenol (1), oleanolic acid (2), hispidulin (3), tyrosol (4), genkwanin (6), and apigenin (7). The relative configuration of compound 5 was established using pip-HSQMBC-IPAP NMR, which afforded accurate long-range 2,3JCH coupling constants. Dereplication enabled the putative annotation of 45 metabolites: 12 flavonoids, 10 chlorogenic acid derivatives, 5 hydroxycinnamic acid derivatives, 9 terpenes, and 9 others. The biological potential of the extracts and isolated metabolites was evaluated using antioxidant, cytotoxic, antimicrobial, and antileishmanial assays. The new phenolic glycoside (8) showed potent antioxidant activity (ABTS: 1111 μmol TE g–1; FRAP: 4293 μmol Fe(II) g–1). Oleanolic acid (MIC = 130 μg mL–1) and apigenin (MIC = 30 μg mL–1) showed activity against the Gram-positive bacterium Bacillus cereus. Preliminary cytotoxic screening against HCT-116 cells showed that the dichloromethane fraction inhibited proliferation by 92% at 50 μg mL–1. Antileishmanial evaluation revealed moderate activity of the crude extract, which was significantly enhanced upon fractionation, with the dichloromethane fraction showing the highest activity against intracellular amastigotes (IC50 = 8.23 μg mL–1; SI = 7.87), indicating a selective antiparasitic effect.",
  "abstract_shown": true,
  "affiliations": [
    "Universidade Estadual de Maringá , , Av. Colombo 5790 , , ,",
    "Instituto de Ciências Biomédicas, Universidade de São Paulo , Av. Prof. Lineu Prestes , , ,",
    "Universidade Tecnológica Federal do Paraná , R. Cristo Rei, 19 , , ,",
    "Universidade Estadual de Ponta Grossa , , Av. Carlos Cavalcanti , , ,"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 15,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Tamires Cordeiro"
    },
    {
      "affs": [
        0
      ],
      "name": "Francielli A. P. Valeze"
    },
    {
      "affs": [
        0
      ],
      "name": "Rodolfo B. Balbinot",
      "orcid": "0000-0001-8245-0950"
    },
    {
      "affs": [
        1
      ],
      "name": "Bianca D. B. Sahm",
      "orcid": "0000-0002-1739-5032"
    },
    {
      "affs": [
        0
      ],
      "name": "Fernanda F. Dourado",
      "orcid": "0000-0003-4091-2840"
    },
    {
      "affs": [
        2
      ],
      "name": "Elizabeth F. Pires"
    },
    {
      "affs": [
        2
      ],
      "name": "Aline Pivetta"
    },
    {
      "affs": [
        2
      ],
      "name": "Tatiana S. Tiuman"
    },
    {
      "affs": [
        0
      ],
      "name": "Celso V. Nakamura",
      "orcid": "0000-0002-9911-7369"
    },
    {
      "affs": [
        1
      ],
      "name": "Leticia V. Costa-Lotufo",
      "orcid": "0000-0003-1861-5153"
    },
    {
      "affs": [
        3
      ],
      "name": "Marta R. B. do Carmo"
    },
    {
      "affs": [
        0
      ],
      "name": "Renan V. Viesser",
      "orcid": "0000-0002-4176-6067"
    },
    {
      "affs": [
        0
      ],
      "name": "Ernani A. Basso",
      "orcid": "0000-0001-7554-5206"
    },
    {
      "affs": [
        0
      ],
      "name": "Maria H. Sarragiotto"
    },
    {
      "affs": [
        0
      ],
      "name": "Debora C. Baldoqui",
      "orcid": "0000-0002-5824-8573"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3r2qsd1t8tpr1.bib",
  "cited_by": 0,
  "doi": "10.1021/acsomega.6c06069",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13737026/",
  "id": "3r2qsd1t8tpr1",
  "issns": [
    "2470-1343"
  ],
  "landing_url": "https://pubs.acs.org/acsodf/article/doi/10.1021/acsomega.6c06069/5454638/Two-New-Metabolites-from-Moquiniastrum-sordidum",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
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      "openalex",
      "1110|Phytochemistry and Biological Activities"
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  "openalex": "W7223044210",
  "pdf_url": "https://pubs.acs.org/doi/pdf/10.1021/acsomega.6c06069",
  "pmcid": "PMC13737026",
  "pmid": "42991364",
  "published": "2026-10-20",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/3r2qsd1t8tpr1.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:39Z",
      "native_id": "10.1021/acsomega.6c06069",
      "source": "crossref",
      "url": "https://pubs.acs.org/acsodf/article/doi/10.1021/acsomega.6c06069/5454638/Two-New-Metabolites-from-Moquiniastrum-sordidum"
    },
    {
      "first_seen": "2026-11-09T12:22:20Z",
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  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1110|Phytochemistry and Biological Activities",
      "subfield": "plant-biology"
    }
  ],
  "title": "Two New Metabolites from Moquiniastrum sordidum : Phytochemical Characterization and Multifaceted Bioactivity",
  "title_text": "Two New Metabolites from Moquiniastrum sordidum : Phytochemical Characterization and Multifaceted Bioactivity",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:22:20Z",
  "url": "https://research.draconitic.com/paper/3r2qsd1t8tpr1",
  "venue": "ACS Omega",
  "versions": []
}