{
  "abstract": "DNA polymerase ε (POLE)-mutant endometrial carcinosarcoma (ECS) is a rare clinical lesion. The current study describes the diagnosis and treatment of a woman who presented with yellow vaginal discharge for >2 months; in addition, a literature review was conducted, and the clinical and pathological characteristics, treatment and prognosis of POLE-mutant ECS are discussed. Preoperative endometrial curettage was performed and the patient was diagnosed with poorly differentiated adenocarcinoma. Based on this finding, a total hysterectomy, bilateral adnexectomy and lymph node dissection were performed. A postoperative pathological examination revealed the morphological characteristics of a high-grade carcinosarcoma in the endometrial tumor. The results of immunohistochemical staining showed that the carcinoma was cytokeratin 7-positive (sarcoma, -) and both the carcinoma and sarcoma were vimentin-positive (carcinoma, weak +; sarcoma, +). Additionally, TP53 showed aberrant immunohistochemical overexpression in the carcinoma and sarcoma, and the Ki-67 proliferation index was 80% in carcinosarcoma. Molecular testing revealed a c.1231G>T (p.Val411Leu) mutation in exon 13 of the POLE gene, and mutations in the TP53 gene were detected in exons 5, 6 and 8. Adjuvant therapy was not administered to the patient after surgery, and no recurrence/metastasis was detected during the 18-month follow-up period. These findings indicate that molecular subtyping should be performed routinely in ECS to identify the POLE-mutant subtype and to avoid overtreatment.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Pathology, The Second People's Hospital of Xiaoshan District, Hangzhou, Zhejiang 311200, P.R. China.",
    "Department of Pathology, The First People's Hospital of Xiaoshan District, Hangzhou, Zhejiang 311200, P.R. China."
  ],
  "article_type": "case report",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yanjie Zhang"
    },
    {
      "affs": [
        1
      ],
      "name": "Bin Huang"
    },
    {
      "affs": [
        0
      ],
      "name": "Haiyan Ge"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3r9a24pye2923.bib",
  "cited_by": 0,
  "doi": "10.3892/etm.2026.13340",
  "fulltext_url": "https://europepmc.org/articles/PMC13711148",
  "id": "3r9a24pye2923",
  "issns": [
    "1792-0981",
    "1792-1015"
  ],
  "landing_url": "https://europepmc.org/article/MED/42948049",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Case Report"
    ],
    [
      "openalex",
      "2729|Endometrial and Cervical Cancer Treatments"
    ]
  ],
  "openalex": "W7222947278",
  "pdf_url": "https://europepmc.org/articles/PMC13711148?pdf=render",
  "pmcid": "PMC13711148",
  "pmid": "42948049",
  "published": "2026-10-19",
  "publisher": "Spandidos Publications",
  "ris": "https://research.draconitic.com/paper/3r9a24pye2923.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:34Z",
      "native_id": "MED:42948049",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42948049"
    },
    {
      "first_seen": "2026-10-31T12:21:58Z",
      "native_id": "PMC13711148",
      "source": "pmc",
      "url": "https://doi.org/10.3892/etm.2026.13340"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2729|Endometrial and Cervical Cancer Treatments",
      "subfield": "reproductive-child"
    }
  ],
  "title": "DNA polymerase ε-mutant endometrial carcinosarcoma: A case report and literature review.",
  "title_text": "DNA polymerase ε-mutant endometrial carcinosarcoma: A case report and literature review.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:21:58Z",
  "url": "https://research.draconitic.com/paper/3r9a24pye2923",
  "venue": "Experimental and therapeutic medicine",
  "versions": []
}