{
  "abstract": "Toxic cytoplasmic aggregates containing the nuclear RNA-binding protein TDP-43 form in several neurodegenerative diseases; however, the molecular triggers driving aggregation remain unclear. Epidemiological evidence has linked latent and reactivating herpes simplex virus type-1 (HSV-1) infections to neurodegenerative disease onset, but it is unknown if HSV-1 infection impacts TDP-43 subcellular distribution. Here, we demonstrate that HSV-1 infection of epithelial cells and DRG-derived neurons results in nuclear TDP-43 redistribution and TDP-43 accumulation within distinct nuclear assemblies. Cytoplasmic TDP-43 was not detected under these conditions. Nuclear TDP-43 assembly occurred early in infection and was dependent upon expression of the critical ICP0 regulatory gene. Remarkably, ectopic ICP0 expression in uninfected cells was sufficient for nuclear TDP-43 assembly. Thus, expression of a single viral gene product encoded by a near ubiquitous human herpesvirus can alter TDP-43 nuclear localization. Moreover, our work identifies a potential mechanistic link between herpesvirus infection and neuronal disease factor mislocalization.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden",
    "Department of Microbiology, New York University School of Medicine, New York, NY USA",
    "Institute for Systems Genetics, New York University Langone Health, New York, NY USA"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Shirley E. Braspenning",
      "orcid": "0000-0001-7539-1526"
    },
    {
      "affs": [
        1
      ],
      "name": "Adam T. Silhavy",
      "orcid": "0009-0003-4308-9420"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Nora L. Herzog",
      "orcid": "0000-0002-7813-2420"
    },
    {
      "affs": [
        1
      ],
      "name": "Phoebe A. Chen",
      "orcid": "0009-0008-1389-4337"
    },
    {
      "affs": [
        1
      ],
      "name": "Angus C. Wilson",
      "orcid": "0000-0002-5016-4164"
    },
    {
      "affs": [
        1
      ],
      "name": "Ian J. Mohr",
      "orcid": "0000-0002-4921-1998"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3rcwm5sqvb4w1.bib",
  "cited_by": 0,
  "doi": "10.1007/s13365-026-01349-z",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13710640/",
  "id": "3rcwm5sqvb4w1",
  "issns": [
    "1355-0284",
    "1538-2443"
  ],
  "landing_url": "https://doi.org/10.1007/s13365-026-01349-z",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research"
    ],
    [
      "openalex",
      "2728|Amyotrophic Lateral Sclerosis Research"
    ]
  ],
  "openalex": "W7223683017",
  "pdf_url": "https://link.springer.com/content/pdf/10.1007/s13365-026-01349-z.pdf",
  "pmcid": "PMC13710640",
  "pmid": "42931998",
  "published": "2026-10-26",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/3rcwm5sqvb4w1.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:21:34Z",
      "native_id": "PMC13710640",
      "source": "pmc",
      "url": "https://doi.org/10.1007/s13365-026-01349-z"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2728|Amyotrophic Lateral Sclerosis Research",
      "subfield": "neurology"
    }
  ],
  "title": "HSV-1 ICP0 expression induces formation of nuclear TDP-43 assemblies",
  "title_text": "HSV-1 ICP0 expression induces formation of nuclear TDP-43 assemblies",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:21:34Z",
  "url": "https://research.draconitic.com/paper/3rcwm5sqvb4w1",
  "venue": "Journal of Neurovirology",
  "versions": []
}