{
  "abstract": "This study investigated the combined use of deep eutectic solvents (DESs) and ultrasound-assisted extraction (UAE) for extracting polyphenols from Cornus officinalis (COF). The results revealed that DESs containing choline chloride-acetamide (ChCl-Ace, 1 : 2) yielded the highest extraction efficiency. Optimal extraction conditions included an ultrasonic power of 350 W, a liquid-to-solid ratio of 24 : 1 mL/g, and 45% water content. Eight phenolic compounds in the COF extract were identified using high-performance liquid chromatography-mass spectrometry. According to the SEM observations, the surface structure of the samples was modified by UAE, as indicated by an average pore size of 770 ± 14.32 nm in ChCl-Ace-UAE, which helped release phenolic compounds. Molecular dynamics simulations showed that ChCl-Ace significantly enhanced solute-solvent interactions, particularly with gallic acid and cyanidin-3-O glucoside, leading to improved extraction efficiency. In vitro chemical and cellular assays confirmed that DES-Ace displayed superior antioxidant properties. In addition, the ChCl-Ace-UAE extract (0.5 mg/mL) demonstrated 91.25 ± 0.15% Staphylococcus aureus, 95.48 ± 0.17% Escherichia coli and 93.72 ± 0.36% Propionibacterium acnes inhibition in the antibacterial assay. In summary, the combined use of UAE and DESs offers a promising and eco-friendly approach for extracting valuable compounds from botanical sources.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Pharmacy, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, PR China; Wuhan University School of Pharmaceutical Sciences, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, China",
    "Department of Psychiatry of Wuhan Wudong Hospital, Wuhan, Hubei 430085, PR China",
    "Department of Pharmacy, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, PR China",
    "Department of Pharmacy, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, PR China; Wuhan University School of Pharmaceutical Sciences, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, China. Electronic address: benhongzh@whu.edu.cn",
    "Sinopharm Dongfeng General Hospital, Hubei University of Medicine, Shiyan, Hubei 442001, PR China; Hubei Key Laboratory of Wudang Local Chinese Medicine Research, School of Pharmaceutical Sciences, Hubei University of Medicine, Shiyan, Hubei 442000, China. Electronic address: cfc-811118@163.com",
    "Department of Pharmacy, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, PR China; Health Management Center, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, PR China. Electronic address: rhzhang@whu.edu.cn"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ping Chen"
    },
    {
      "affs": [
        1
      ],
      "name": "Wenhao Xiao"
    },
    {
      "affs": [
        2
      ],
      "name": "李瑞祥"
    },
    {
      "affs": [
        3
      ],
      "name": "Benhong Zhou",
      "orcid": "0000-0002-6129-0182"
    },
    {
      "affs": [
        4
      ],
      "name": "陈富超"
    },
    {
      "affs": [
        5
      ],
      "name": "Ruhong Zhang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3rdq65zxs760p.bib",
  "cited_by": 5,
  "doi": "10.1016/j.ultsonch.2026.107909",
  "fulltext_url": null,
  "id": "3rdq65zxs760p",
  "issns": [
    "1350-4177",
    "1873-2828"
  ],
  "landing_url": "https://doi.org/10.1016/j.ultsonch.2026.107909",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1606|Ionic liquids properties and applications"
    ]
  ],
  "openalex": "W7163019575",
  "pdf_url": null,
  "pmcid": "PMC13265695",
  "pmid": "42241829",
  "published": "2026-06-01",
  "publisher": "Elsevier BV",
  "ris": "https://research.draconitic.com/paper/3rdq65zxs760p.ris",
  "sources": [
    {
      "first_seen": "2026-11-07T13:20:46Z",
      "native_id": "W7163019575",
      "source": "openalex",
      "url": "https://doi.org/10.1016/j.ultsonch.2026.107909"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1606|Ionic liquids properties and applications",
      "subfield": "physical"
    }
  ],
  "title": "Ultrasound-assisted deep eutectic solvent extraction of polyphenols from Cornus officinalis: Optimization, mechanisms, and bioactivity",
  "title_text": "Ultrasound-assisted deep eutectic solvent extraction of polyphenols from Cornus officinalis: Optimization, mechanisms, and bioactivity",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T13:20:39Z",
  "url": "https://research.draconitic.com/paper/3rdq65zxs760p",
  "venue": "Ultrasonics Sonochemistry",
  "versions": []
}