{
  "abstract": "Suppressive antiretroviral therapy (ART) in people with HIV (PWH) arrests progression to AIDS and onward viral transmission. However, viral transcription from integrated HIV-1 proviruses persists on treatment and is linked to markers of chronic immune activation, contributing to the accelerated development of comorbidities in PWH. Of particular interest are persistent responses in long-lived tissue-resident myeloid cells, which direct tissue-level inflammatory processes through cytokine secretion and interactions with other immune cell populations. Here, we review recent findings on viral nucleic acid sensing events in HIV-infected myeloid cells to shed light on possible mechanisms of persistent inflammation resulting from chronic HIV-1 transcription in myeloid cells in PWH.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Virology, Immunology, & Microbiology, Boston University Chobanian & Avedisian School of Medicine"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ivy K. Hughes",
      "orcid": "0000-0002-8769-4011"
    },
    {
      "affs": [
        0
      ],
      "name": "Suryaram Gummuluru",
      "orcid": "0000-0002-8606-8481"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3rhj13m1vvn66.bib",
  "cited_by": 0,
  "doi": "10.1128/mbio.03340-25",
  "fulltext_url": null,
  "id": "3rhj13m1vvn66",
  "issns": [
    "2150-7511"
  ],
  "landing_url": "https://journals.asm.org/doi/10.1128/mbio.03340-25",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2406|HIV Research and Treatment"
    ]
  ],
  "openalex": "W7222999926",
  "pdf_url": "https://journals.asm.org/doi/pdf/10.1128/mbio.03340-25",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-20",
  "publisher": "American Society for Microbiology",
  "ris": "https://research.draconitic.com/paper/3rhj13m1vvn66.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:28Z",
      "native_id": "10.1128/mbio.03340-25",
      "source": "crossref",
      "url": "https://journals.asm.org/doi/10.1128/mbio.03340-25"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2406|HIV Research and Treatment",
      "subfield": "microbiology"
    }
  ],
  "title": "mGem: Innate immune sensing of HIV-1 transcription in myeloid cells—a tale of two transcription start sites",
  "title_text": "mGem: Innate immune sensing of HIV-1 transcription in myeloid cells—a tale of two transcription start sites",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:28Z",
  "url": "https://research.draconitic.com/paper/3rhj13m1vvn66",
  "venue": "mBio",
  "versions": []
}