{
  "abstract": "While high-valent metal-halide complexes are widely studied as oxidants that promote C-H activation, their Lewis acidic reactivity has received little attention. Herein, we report a new mode of Cu(III) reactivity in which Lewis acidic Cu(III) complexes activate C(sp3)-OH bond in alcohols and convert them to the corresponding alkyl fluorides, chlorides, and bromides. A series of formal Cu(III) halide complexes (X = F, Cl, Br) supported by the tris(2-pyridylthio)methanide (TPTM, L) ligand were synthesized. These trigonal-bipyramidal [LCuIII-X]+ complexes feature an anionic carbon donor trans to the halide, resulting in weakened Cu-X bonds. Unlike conventional Cu(III) complexes that typically promote hydrogen atom abstraction, [LCuIII-X]+ instead activates the C(sp3)-OH bond for deoxyhalogenation. Mechanistic studies suggest that the reaction proceeds through initial activation of the C(sp3)-OH bond by the Lewis acidic CuIII center to generate a carbocation intermediate, which is subsequently trapped by halides to form the C(sp3)-X bond. While Lewis acid-promoted deoxychlorination and deoxybromination reactions have been reported previously, this study represents the first example of a metal complex capable of mediating a general deoxyhalogenation series including F, Cl, and Br transfer.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio43210, United States."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Joshua A Queener"
    },
    {
      "affs": [
        0
      ],
      "name": "Ashleigh N Sherman"
    },
    {
      "affs": [
        0
      ],
      "name": "Abigail M Houser",
      "orcid": "0009-0003-8090-7082"
    },
    {
      "affs": [
        0
      ],
      "name": "Shiyu Zhang",
      "orcid": "0000-0002-2536-4324"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3rkp9zpn6az2t.bib",
  "cited_by": 0,
  "doi": "10.1021/acs.inorgchem.6c03041",
  "fulltext_url": "https://europepmc.org/articles/PMC13625957",
  "id": "3rkp9zpn6az2t",
  "issns": [
    "0020-1669",
    "1520-510X"
  ],
  "landing_url": "https://europepmc.org/article/MED/42916477",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1604|Metal-Catalyzed Oxygenation Mechanisms"
    ]
  ],
  "openalex": "W7212934303",
  "pdf_url": "https://europepmc.org/articles/PMC13625957?pdf=render",
  "pmcid": "PMC13625957",
  "pmid": "42916477",
  "published": "2026-09-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/3rkp9zpn6az2t.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:02Z",
      "native_id": "MED:42916477",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42916477"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1604|Metal-Catalyzed Oxygenation Mechanisms",
      "subfield": "inorganic"
    }
  ],
  "title": "Deoxyhalogenation with Cu(III) Halide Complexes.",
  "title_text": "Deoxyhalogenation with Cu(III) Halide Complexes.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:02Z",
  "url": "https://research.draconitic.com/paper/3rkp9zpn6az2t",
  "venue": "Inorganic chemistry",
  "versions": []
}