{
  "abstract": "MicroRNA-215 (miR-215), a highly conserved non-coding small molecule, plays a significant regulatory role in the maintenance of cellular homeostasis, tissue and organ development, and the pathogenesis of various diseases. In recent years, accumulating evidence has revealed that miR-215 is extensively and complexly involved in digestive system diseases, drawing considerable attention due to its aberrant expression and functional diversity across multiple digestive organs. Notably, miR-215 can exert diametrically opposing biological functions in different digestive organs, and even within the same organ under distinct pathological contexts, underscoring its unique property as a “dual-functional small molecule” and providing an ideal paradigm for deciphering the regulatory complexity of microRNA networks. This review systematically summarizes the discovery and sequence conservation features of miR-215, with a particular focus on its differential expression patterns in major digestive organs. We further dissect the molecular mechanisms underlying its pathological context-dependent functional switching in intestinal disorders, gastric cancer, and hepatic lesions, and evaluate its potential utility as a biomarker for the diagnosis and prognosis of digestive tract diseases. Collectively, this review aims to provide a theoretical foundation and novel insights for the early detection, prognostic assessment, and precision-targeted therapy of digestive system disorders.",
  "abstract_shown": true,
  "affiliations": [
    "College of Biology and Agriculture, Shaoguan University, Shaoguan 512005, China"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Mao Zhang",
      "orcid": "0000-0001-6354-8709"
    },
    {
      "affs": [
        0
      ],
      "name": "Hailing Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Jinna Yang"
    },
    {
      "affs": [
        0
      ],
      "name": "Xinyuan Lei"
    },
    {
      "affs": [
        0
      ],
      "name": "Shuang Gao"
    },
    {
      "affs": [
        0
      ],
      "name": "Yiming Yan"
    },
    {
      "affs": [
        0
      ],
      "name": "Hongyi Li"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3rmmr4ffnxzqd.bib",
  "cited_by": 0,
  "doi": "10.3390/biom16111583",
  "fulltext_url": null,
  "id": "3rmmr4ffnxzqd",
  "issns": [
    "2218-273X"
  ],
  "landing_url": "https://www.mdpi.com/2218-273X/16/11/1583",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-01",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/3rmmr4ffnxzqd.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T00:23:55Z",
      "native_id": "10.3390/biom16111583",
      "source": "crossref",
      "url": "https://www.mdpi.com/2218-273X/16/11/1583"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "issn:2218-273X",
      "subfield": "general"
    }
  ],
  "title": "Dualistic Roles of MiR-215 in Digestive System Disorders: From Physiology to Pathology",
  "title_text": "Dualistic Roles of MiR-215 in Digestive System Disorders: From Physiology to Pathology",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T00:24:50Z",
  "url": "https://research.draconitic.com/paper/3rmmr4ffnxzqd",
  "venue": "Biomolecules",
  "versions": []
}