{
  "abstract": "Background: Colorectal cancer progression involves mitophagy, in which Prohibitin 2 (PHB2) regulates the PARL–PGAM5–PINK1 axis. Scutellarein has antitumor activity but poor bioavailability. We developed integrin αvβ3-targeted β-cyclodextrin-based scutellarein nanoparticles (Scu-NPs), which enhance the solubility, stability, and tumor-targeting of scutellarein, and investigated whether they suppress colon cancer via PHB2-mediated mitophagy inhibition and modulate tumor-associated depression and osteotropic migration.\n\nMethods: PHB2 expression and mitochondrial localization were examined in colon cancer cells. SW480 cells with PHB2 overexpression were treated with Scu or Scu-NPs. Proliferation, migration, invasion, apoptosis, mitochondrial function, and mitophagy-related proteins were assessed. Subcutaneous xenografts, a chronic unpredictable mild stress tumor–depression model, behavioral tests, osteotropic migration assays, and bioinformatics were used.\n\nResults: PHB2 was highly expressed and mitochondria-localized in colon cancer cells. Scu-NPs downregulated PHB2, increased PARL, decreased PGAM5, PINK1, Parkin, and LC3-II/LC3-I, and increased P62, indicating mitophagy inhibition. Scu-NPs induced mitochondrial dysfunction, ROS accumulation, apoptosis, and inhibited proliferation, migration, and invasion; PHB2 overexpression partially reversed these effects. In vivo , Scu-NPs suppressed xenograft growth and improved depressive-like behaviors, with PHB2 overexpression attenuating these effects. In vitro , Scu-NPs reduced colon cancer cell migration toward osteoblast-conditioned medium, whereas PHB2 overexpression partially reversed this effect.\n\nConclusion: Scu-NPs suppress colon cancer by downregulating PHB2 and inhibiting mitophagy. PHB2 may serve as a shared molecular node linking tumor progression, depressive-like behaviors, and osteotropic migration, supporting Scu-NPs as a multi-target strategy.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Anorectal Surgery, Shenzhen TCM Anorectal Hospital (Futian)"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yuanzhi Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Hao Xu"
    },
    {
      "affs": [
        0
      ],
      "name": "Zonglin Cai"
    },
    {
      "affs": [
        0
      ],
      "name": "Shimei Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Xuqiang Luo"
    },
    {
      "affs": [
        0
      ],
      "name": "Jinghua Liang"
    },
    {
      "affs": [
        0
      ],
      "name": "Yingying Liao"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3rnx0byhvfmkv.bib",
  "cited_by": 0,
  "doi": "10.3389/fpubh.2026.1996414",
  "fulltext_url": null,
  "id": "3rnx0byhvfmkv",
  "issns": [
    "2296-2565"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fpubh.2026.1996414/full",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2713|Autophagy in Disease and Therapy"
    ]
  ],
  "openalex": "W7224100418",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-28",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/3rnx0byhvfmkv.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:24Z",
      "native_id": "10.3389/fpubh.2026.1996414",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fpubh.2026.1996414/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Autophagy in Disease and Therapy",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Scutellarein nanoparticles suppress colon cancer via PHB2-mediated mitophagy inhibition with modulatory effects on tumor-associated depression and osteotropic migration",
  "title_text": "Scutellarein nanoparticles suppress colon cancer via PHB2-mediated mitophagy inhibition with modulatory effects on tumor-associated depression and osteotropic migration",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:24Z",
  "url": "https://research.draconitic.com/paper/3rnx0byhvfmkv",
  "venue": "Frontiers in Public Health",
  "versions": []
}