{
  "abstract": "This study evaluated the effects of dietary n-3 polyunsaturated fatty acids (n-3 PUFA) supplementation on endocrine and metabolic profiles of forty-five nulliparous rabbit does during their first reproductive cycle. Animals were randomly assigned to one of three diets: control (CNT), 5% extruded linseed (L), and 5% extruded linseed plus 0.2% Padina pavonica extract (LPP). Blood was sampled at baseline, artificial insemination, parturition, mid-lactation, and weaning, to determine the concentrations of cortisol, insulin, leptin, thyroid hormones (T₃, T₄), glucose, and non-esterified fatty acids (NEFA). Reproductive stage significantly influenced endocrine and metabolic dynamics, with cortisol and NEFA peaking at parturition (p < 0.001). Supplemented groups, particularly LPP, showed higher T₃ concentrations (p < 0.05) and T₃/T₄ ratios (p < 0.01). The L diet maintained higher insulin during lactation (p < 0.05), while LPP lowered leptin at parturition (p < 0.01) and NEFA at insemination (p < 0.01), indicating an early decrease in lipid mobilization. Multivariate analysis suggested that n-3 PUFA supplementation promoted an endocrine profile characterized by enhanced thyroid activity and reduced lipid mobilization, consistent with a potentially favorable metabolic shift. In conclusion, enriching diets with n-3 PUFA, especially linseed combined with Padina pavonica extract, represents a promising nutritional strategy to support rabbit does during the highly demanding phases of their first reproductive cycle.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Veterinary Medicine and Animal Sciences, University of Milan, Lodi, Italy.",
    "Department of Veterinary Medicine, University of Perugia, Perugia, Italy.",
    "Faculty of Veterinary Medicine, Agricultural University of Tirana, Tirana, Albania.",
    "Department of Life Science, Health and Health Professions, Università degli Studi \"Link Campus University\", Rome, Italy.",
    "Department of Veterinary Medicine, University of Sassari, Sassari, Italy.",
    "Department of Agricultural, Food and Environmental Science, University of Perugia, Perugia, Italy.",
    "LR13AGR02, Mateur Higher School of Agriculture, University of Carthage, Mateur, Tunisia.",
    "School of Biosciences and Veterinary Medicine, University of Camerino, Matelica, Italy."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 15,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Alda Quattrone"
    },
    {
      "affs": [
        0
      ],
      "name": "Nour Elhouda Fehri"
    },
    {
      "affs": [
        1
      ],
      "name": "Olimpia Barbato"
    },
    {
      "affs": [
        1
      ],
      "name": "Giovanni Ricci"
    },
    {
      "affs": [
        0
      ],
      "name": "Daniele Vigo"
    },
    {
      "affs": [
        2
      ],
      "name": "Luigj Turmalaj"
    },
    {
      "affs": [
        2
      ],
      "name": "Majlind Sulçe"
    },
    {
      "affs": [
        3
      ],
      "name": "Marta Castrica"
    },
    {
      "affs": [
        4
      ],
      "name": "Maria Laura Marongiu"
    },
    {
      "affs": [
        5
      ],
      "name": "Alessandro Dal Bosco"
    },
    {
      "affs": [
        6
      ],
      "name": "Bayrem Jemmali"
    },
    {
      "affs": [
        2
      ],
      "name": "Gerald Muça"
    },
    {
      "affs": [
        1
      ],
      "name": "Gabriele Brecchia"
    },
    {
      "affs": [
        0
      ],
      "name": "Giulio Curone"
    },
    {
      "affs": [
        7
      ],
      "name": "Laura Menchetti"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3rqthmk09082a.bib",
  "cited_by": 0,
  "doi": "10.1080/01652176.2026.2749322",
  "fulltext_url": "https://europepmc.org/articles/PMC13721818",
  "id": "3rqthmk09082a",
  "issns": [
    "0165-2176",
    "1875-5941"
  ],
  "landing_url": "https://europepmc.org/article/MED/42954948",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "1103|Rabbits: Nutrition, Reproduction, Health"
    ]
  ],
  "openalex": "W7224661504",
  "pdf_url": "https://europepmc.org/articles/PMC13721818?pdf=render",
  "pmcid": "PMC13721818",
  "pmid": "42954948",
  "published": "2026-10-29",
  "publisher": "Taylor & Francis",
  "ris": "https://research.draconitic.com/paper/3rqthmk09082a.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T00:20:36Z",
      "native_id": "MED:42954948",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42954948"
    },
    {
      "first_seen": "2026-11-03T12:22:26Z",
      "native_id": "PMC13721818",
      "source": "pmc",
      "url": "https://doi.org/10.1080/01652176.2026.2749322"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1103|Rabbits: Nutrition, Reproduction, Health",
      "subfield": "zoology-behaviour"
    }
  ],
  "title": "Hormonal and metabolic adaptations in Omega-3-supplemented rabbit does during their first reproductive cycle.",
  "title_text": "Hormonal and metabolic adaptations in Omega-3-supplemented rabbit does during their first reproductive cycle.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:22:26Z",
  "url": "https://research.draconitic.com/paper/3rqthmk09082a",
  "venue": "The veterinary quarterly",
  "versions": []
}