{
  "abstract": "Elevated lipoprotein (a) (Lp[a]) is becoming increasingly recognized as a cardiovascular disease risk factor. The relationship of Lp(a) to cardiovascular disease is well characterized in European populations; however, data are lacking in the Asian region. In this scoping review, we aimed to characterize the distribution and prevalence of elevated Lp(a) in the Asian region and its relationship to coronary artery disease, cerebrovascular disease, and peripheral vascular disease. Thirty-one Asian studies met the inclusion criteria and were compared with 6 representative European studies. The greatest representation was in Chinese populations, with much less representation of Japanese, Thai, Indian, and other groups. Levels of Lp(a) in healthy Asian populations were generally lower than in Europid (Caucasian) populations; however, these levels remain lower than those reported in European literature. Within Asian populations, elevated Lp(a) was universally associated with increased risk of coronary artery disease and peripheral vascular disease. The relationship with stroke was less clear.",
  "abstract_shown": true,
  "affiliations": [
    "Northern Health, Epping, Australia.",
    "Department of Endocrinology, Changi General Hospital, Singapore, Singapore.",
    "Division of Endocrinology and Metabolism, Department of Medicine, School of Clinical Medicine, Li KaShing Faculty of Medicine, The University of Hong Kong, Hong Kong, China; Queen Mary Hospital, Hong Kong SAR, China.",
    "Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kanazawa University Kanazawa, Kanazawa, Japan.",
    "Department of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.",
    "Ziauddin University Hospital, North Nazimabad, Karachi, Pakistan.",
    "Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates.",
    "Faculty of Medical Sciences, University of Sri Jayewardenepura, Gangodawila, Nugegoda, Sri Lanka.",
    "National University Heart Center Singapore, Singapore, Singapore.",
    "Fuwai Hospital, Beijing, China.",
    "Victorian Heart Institute, Monash University, Clayton, Australia.",
    "National Cerebral and Cardiovascular Center, Osaka, Japan.",
    "Kokilaben Hospital, Andheri West, Mumbai, India.",
    "Department of Cardiology, Royal Adelaide Hospital, Adelaide, Australia.",
    "Section of Cardiology, Department of Medicine, Aga Khan University, Karachi, Pakistan; Department of Population Health, Aga Khan University, Nairobi, Kenya.",
    "Departments of Medical Education and Medicine, Melbourne Medical School, University of Melbourne, Parkville, Australia. Electronic address: robrien@unimelb.edu.au."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 18,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Matthew D'Amore"
    },
    {
      "affs": [
        1
      ],
      "name": "Wann Jia Loh"
    },
    {
      "affs": [
        2
      ],
      "name": "David Tak Wai Lui"
    },
    {
      "affs": [
        3
      ],
      "name": "Hayato Tada"
    },
    {
      "affs": [
        4
      ],
      "name": "Rungroj Krittayaphong"
    },
    {
      "affs": [
        5
      ],
      "name": "Khalida Soomro"
    },
    {
      "affs": [
        6
      ],
      "name": "Wael Almahmeed"
    },
    {
      "affs": [
        7
      ],
      "name": "Thushara Matthias"
    },
    {
      "affs": [
        8
      ],
      "name": "Kian Keong Poh"
    },
    {
      "affs": [
        9
      ],
      "name": "Jian Jun Li"
    },
    {
      "affs": [
        10
      ],
      "name": "Julie Butters"
    },
    {
      "affs": [
        11
      ],
      "name": "Yu Kataoka"
    },
    {
      "affs": [
        8
      ],
      "name": "Mayank Dalakoti"
    },
    {
      "affs": [
        12
      ],
      "name": "Jamshed J Dalal"
    },
    {
      "affs": [
        13
      ],
      "name": "Adam Nelson"
    },
    {
      "affs": [
        14
      ],
      "name": "Salim S Virani"
    },
    {
      "affs": [
        10
      ],
      "name": "Stephen J Nicholls"
    },
    {
      "affs": [
        15
      ],
      "name": "Richard C O'Brien"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3rxm261c5963f.bib",
  "cited_by": 0,
  "doi": "10.1016/j.jacasi.2026.07.046",
  "fulltext_url": "https://europepmc.org/articles/PMC13654413",
  "id": "3rxm261c5963f",
  "issns": [
    "2772-3747"
  ],
  "landing_url": "https://europepmc.org/article/MED/42841558",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2746|Lipoproteins and Cardiovascular Health"
    ]
  ],
  "openalex": "W7220657524",
  "pdf_url": "https://europepmc.org/articles/PMC13654413?pdf=render",
  "pmcid": "PMC13654413",
  "pmid": "42841558",
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/3rxm261c5963f.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:10Z",
      "native_id": "MED:42841558",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42841558"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Lipoproteins and Cardiovascular Health",
      "subfield": "surgery"
    }
  ],
  "title": "Elevated Lipoprotein(a) in Asian Populations and its Implications for Cardiovascular Disease.",
  "title_text": "Elevated Lipoprotein(a) in Asian Populations and its Implications for Cardiovascular Disease.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:10Z",
  "url": "https://research.draconitic.com/paper/3rxm261c5963f",
  "venue": "JACC. Asia",
  "versions": []
}