{
  "abstract": "Acute myeloid leukemia (AML) is a fatal disease characterized by a bleak prognosis. For over four decades, treatment options for AML have been constrained to administering high-dose cytotoxic chemotherapy. However, the emergence of drug resistance and the resultant toxic side effects have created an urgent necessity for identifying novel therapeutic targets. In this study, non-receptor protein tyrosine phosphatase type 2 (PTPN2) is highly expressed in AML. Remarkably, knockdown of PTPN2 expression markedly mitigated AML burden both in vitro and in vivo. Additionally, we unveiled the direct interaction between PTPN2 and c-MYC, establishing c-MYC as a direct acting substrate of PTPN2. Then, we obtained a small-molecule inhibitor, WS35, which has good inhibitory activity against PTPN2. Moreover, WS35 shows a strong therapeutic effect in vivo for AML. In conclusion, these results indicate the carcinogenic mechanism of PTPN2, and the therapeutic strategies targeting PTPN2 have significant potential for treating AML.",
  "abstract_shown": true,
  "affiliations": [
    "State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China",
    "Institute of Innovative Drug, China Pharmaceutical University, Nanjing 211198, China",
    "Department of Clinical Laboratory, Jiangsu Province Hospital of Chinese Medicine, Nanjing 210029, China"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Wenbin Kuang"
    },
    {
      "affs": [
        0
      ],
      "name": "Dawei Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Mingge Song"
    },
    {
      "affs": [
        0
      ],
      "name": "Jianing Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Jiaxing Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Wenmu Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Anyan Chen"
    },
    {
      "affs": [
        1
      ],
      "name": "Ya Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Jiayu Ding"
    },
    {
      "affs": [
        0
      ],
      "name": "Liping Wang"
    },
    {
      "affs": [
        2
      ],
      "name": "Wanjian Gu"
    },
    {
      "affs": [
        0
      ],
      "name": "Yibei Xiao"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiao Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Peng Yang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3s12rshf9wxfb.bib",
  "cited_by": 0,
  "doi": "10.48130/targetome-0026-0052",
  "fulltext_url": "https://www.maxapress.com/article/doi/10.48130/targetome-0026-0052",
  "id": "3s12rshf9wxfb",
  "issns": [
    "3071-0596",
    "3070-3808"
  ],
  "landing_url": "https://doi.org/10.48130/targetome-0026-0052",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RM1-950"
    ],
    [
      "openalex",
      "1312|Protein Tyrosine Phosphatases"
    ]
  ],
  "openalex": "W7222648106",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-01",
  "publisher": "Maximum Academic Press",
  "ris": "https://research.draconitic.com/paper/3s12rshf9wxfb.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T14:21:24Z",
      "native_id": "27f89da1af8e4158bd2bb8607f11392a",
      "source": "doaj",
      "url": "https://doi.org/10.48130/targetome-0026-0052"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Protein Tyrosine Phosphatases",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Targeting PTPN2-mediated dephosphorylation destabilizes c-MYC and suppresses acute myeloid leukemia survival",
  "title_text": "Targeting PTPN2-mediated dephosphorylation destabilizes c-MYC and suppresses acute myeloid leukemia survival",
  "type": "peer-reviewed",
  "updated_at": "2026-11-05T14:20:19Z",
  "url": "https://research.draconitic.com/paper/3s12rshf9wxfb",
  "venue": "Targetome",
  "versions": []
}