{
  "abstract": "The reactivity of [Rh(H)(PEt ₃ ) ₃ ] ( 1 ) toward α‐fluorinated ethers that are commonly used as inhalational anesthetics was studied. Unprecedented reactivity pathways include hydrodehalogenation of sp ³ C─F and C─Cl bonds under mild conditions. The reaction of 1 with sevoflurane (CF ₃ ) ₂ CHOCH ₂ F provides an efficient route to obtain [Rh(F)(PEt ₃ ) ₃ ] ( 2 ) by C( sp ³ )─F bond activation. Furthermore, the phosphine ligand takes part in this reaction, and an F/Et exchange at [Rh(H)(F) ₂ (PEt ₃ ) ₃ ] results in the formation of the fluorophosphine complex trans ‐[Rh(F)(Et ₂ PF)(PEt ₃ ) ₂ ] ( 5 ) upon the release of ethane. On the other hand, an oxidative addition of enflurane CClFHCF ₂ OCF ₂ H at 1 yielded [Rh(H)(Cl)(CFHCF ₂ OCF ₂ H)(PEt ₃ ) ₃ ] ( 8 ), which is followed by a reductive elimination step to yield [Rh(Cl)(PEt ₃ ) ₃ ] ( 7 ) and the hydrofluoroether CFH ₂ CF ₂ OCF ₂ H. When an isomer of enflurane, isoflurane CF ₃ CClHOCF ₂ H, was treated with 1 , complex 7 and CF ₃ CH ₂ OCF ₂ H are generated by C( sp ³ )─Cl bond activation. Additionally, an in situ nucleophilic attack of triethylphosphine at the hydrofluoroether CF ₃ CH ₂ OCF ₂ H gave a unique fluorinated phosphonium salt [CF ₃ CH ₂ PEt ₃ ] ₂ [SiF ₆ ] ( 9 ). Catalytic hydrodechlorination of isoflurane at a mild condition was achieved in the presence of silane HSiPh ₃ using 1 as a catalyst.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Chemistry Humboldt‐Universität zu Berlin Berlin Germany"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
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        0
      ],
      "name": "Soodeh Mollasalehi",
      "orcid": "0009-0000-6284-0337"
    },
    {
      "affs": [
        0
      ],
      "name": "Jakob Bölle",
      "orcid": "0009-0008-9919-7371"
    },
    {
      "affs": [
        0
      ],
      "name": "Thomas Braun",
      "orcid": "0000-0003-1629-5352"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3sjv53106mcyw.bib",
  "cited_by": 0,
  "doi": "10.1002/open.70328",
  "fulltext_url": "https://europepmc.org/articles/PMC13724305",
  "id": "3sjv53106mcyw",
  "issns": [
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    "2191-1363"
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  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "http://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
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      "openalex",
      "1605|Organometallic Complex Synthesis and Catalysis"
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  "openalex": "W7203721177",
  "pdf_url": "https://chemistry-europe.onlinelibrary.wiley.com/doi/pdf/10.1002/open.70328",
  "pmcid": "PMC13724305",
  "pmid": "42967868",
  "published": "2026-11-01",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/3sjv53106mcyw.ris",
  "sources": [
    {
      "first_seen": "2026-11-02T12:22:53Z",
      "native_id": "10.1002/open.70328",
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      "url": "https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/open.70328"
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    {
      "first_seen": "2026-11-03T15:20:53Z",
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      "url": "https://europepmc.org/article/MED/42967868"
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    {
      "first_seen": "2026-11-04T12:22:54Z",
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      "url": "https://doi.org/10.1002/open.70328"
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  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Organometallic Complex Synthesis and Catalysis",
      "subfield": "organic"
    }
  ],
  "title": "Reactivity of Rh(I) Complexes Toward Fluorinated Ethers: Activation of Inhalation Anesthetics",
  "title_text": "Reactivity of Rh(I) Complexes Toward Fluorinated Ethers: Activation of Inhalation Anesthetics",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:20:50Z",
  "url": "https://research.draconitic.com/paper/3sjv53106mcyw",
  "venue": "ChemistryOpen",
  "versions": [
    {
      "doi": "10.26434/chemrxiv.15007557/v1",
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}